Targeting EGFR Exon 20 Insertions in Non–Small Cell Lung Cancer: Recent Advances and Clinical Updates
CB Meador, LV Sequist, Z Piotrowska - Cancer discovery, 2021 - AACR
… features of EGFR ins20 mutations and summarize recent data on emerging therapies for
patients with this subtype of EGFR-mutant non–small cell lung cancer (NSCLC). …
patients with this subtype of EGFR-mutant non–small cell lung cancer (NSCLC). …
Concurrent EGFR‐TKI and thoracic radiotherapy as first‐line treatment for stage IV non‐small cell lung cancer harboring EGFR active mutations
LP Zheng, Y Wang, Z Xu, Q Yang, G Zhu… - The …, 2019 - academic.oup.com
… EGFR‐tyrosine kinase inhibitor (TKI) combined with radiotherapy at metastatic sites in advanced
lung cancer harboring EGFR active mutations… local disease during EGFR‐TKI treatment. …
lung cancer harboring EGFR active mutations… local disease during EGFR‐TKI treatment. …
[HTML][HTML] Concurrent RB1 and TP53 alterations define a subset of EGFR-mutant lung cancers at risk for histologic transformation and inferior clinical outcomes
… of lung adenocarcinomas harbor a sensitizing EGFR mutation. Patients with EGFR-mutant
lung cancers have robust responses to EGFR tyrosine kinase inhibitors (EGFR-TKIs) but …
lung cancers have robust responses to EGFR tyrosine kinase inhibitors (EGFR-TKIs) but …
Clinical significance of EGFR mutation types in lung adenocarcinoma: A multi-centre Korean study
HY Yoon, JS Ryu, YS Sim, D Kim, SY Lee, J Choi… - PLoS …, 2020 - journals.plos.org
… of EGFR mutations in advanced lung adenocarcinoma can … than other mutations, while
an E21 mutation is expected to … for good prognosis in EGFR positive lung cancer, similar to …
an E21 mutation is expected to … for good prognosis in EGFR positive lung cancer, similar to …
Randomized Trial of First-Line Tyrosine Kinase Inhibitor With or Without Radiotherapy for Synchronous Oligometastatic EGFR-Mutated Non-Small Cell Lung Cancer
XS Wang, YF Bai, V Verma, RL Yu… - … the National Cancer …, 2023 - academic.oup.com
… lung cancer (NSCLC). Whether these findings translate to epidermal growth factor receptor
(EGFR)–mutated … (TKI) therapy for EGFR-mutated synchronous oligometastatic NSCLC and …
(EGFR)–mutated … (TKI) therapy for EGFR-mutated synchronous oligometastatic NSCLC and …
Machine learning-based radiomics signatures for EGFR and KRAS mutations prediction in non-small-cell lung cancer
… strategy for specific individuals carrying mutations associated with improved sensitivity to …
of only 6 EGFR mutation carriers in the validation set compared with 12 EGFR wild-type carriers…
of only 6 EGFR mutation carriers in the validation set compared with 12 EGFR wild-type carriers…
[HTML][HTML] Afatinib for the Treatment of Non-Small Cell Lung Cancer Harboring Uncommon EGFR Mutations: An Updated Database of 1023 Cases Brief Report
… a database of 693 patients with NSCLC and uncommon EGFR mutations treated with
afatinib. Here, we provide an update of >1000 patients, with more data on specific mutations. …
afatinib. Here, we provide an update of >1000 patients, with more data on specific mutations. …
The role of EGFR mutation as a prognostic factor in survival after diagnosis of brain metastasis in non-small cell lung cancer: a systematic review and meta-analysis
WY Li, TT Zhao, HM Xu, ZN Wang, YY Xu, Y Han… - BMC cancer, 2019 - Springer
… illustrated that EGFR mutations are significantly … EGFR mutations and OS for these patients
[20,21,22,23,24,25,26,27,28,29]. Two studies have even suggested that EGFR mutations may …
[20,21,22,23,24,25,26,27,28,29]. Two studies have even suggested that EGFR mutations may …
Epidemiological and clinical burden of EGFR Exon 20 insertion in advanced non-small cell lung cancer: A systematic literature review
H Burnett, H Emich, C Carroll, N Stapleton… - PLoS …, 2021 - journals.plos.org
… the prognostic impact of Exon 20ins were heterogeneous but highlighted poorer outcomes
in patients with Exon 20ins mutation compared with patients with other EGFR mutations and …
in patients with Exon 20ins mutation compared with patients with other EGFR mutations and …
Mining whole-lung information by artificial intelligence for predicting EGFR genotype and targeted therapy response in lung cancer: a multicohort study
… We found 14 studies that used deep learning and CT imaging to predict EGFR mutation
status in patients with lung cancer. The largest dataset obtained so far included 914 patients in a …
status in patients with lung cancer. The largest dataset obtained so far included 914 patients in a …