Targeting EGFR Exon 20 Insertions in Non–Small Cell Lung Cancer: Recent Advances and Clinical Updates

CB Meador, LV Sequist, Z Piotrowska - Cancer discovery, 2021 - AACR
… features of EGFR ins20 mutations and summarize recent data on emerging therapies for
patients with this subtype of EGFR-mutant non–small cell lung cancer (NSCLC). …

Concurrent EGFR‐TKI and thoracic radiotherapy as first‐line treatment for stage IV non‐small cell lung cancer harboring EGFR active mutations

LP Zheng, Y Wang, Z Xu, Q Yang, G Zhu… - The …, 2019 - academic.oup.com
EGFR‐tyrosine kinase inhibitor (TKI) combined with radiotherapy at metastatic sites in advanced
lung cancer harboring EGFR active mutations… local disease during EGFR‐TKI treatment. …

[HTML][HTML] Concurrent RB1 and TP53 alterations define a subset of EGFR-mutant lung cancers at risk for histologic transformation and inferior clinical outcomes

M Offin, JM Chan, M Tenet, HA Rizvi, R Shen… - Journal of Thoracic …, 2019 - Elsevier
… of lung adenocarcinomas harbor a sensitizing EGFR mutation. Patients with EGFR-mutant
lung cancers have robust responses to EGFR tyrosine kinase inhibitors (EGFR-TKIs) but …

Clinical significance of EGFR mutation types in lung adenocarcinoma: A multi-centre Korean study

HY Yoon, JS Ryu, YS Sim, D Kim, SY Lee, J Choi… - PLoS …, 2020 - journals.plos.org
… of EGFR mutations in advanced lung adenocarcinoma can … than other mutations, while
an E21 mutation is expected to … for good prognosis in EGFR positive lung cancer, similar to …

Randomized Trial of First-Line Tyrosine Kinase Inhibitor With or Without Radiotherapy for Synchronous Oligometastatic EGFR-Mutated Non-Small Cell Lung Cancer

XS Wang, YF Bai, V Verma, RL Yu… - … the National Cancer …, 2023 - academic.oup.com
lung cancer (NSCLC). Whether these findings translate to epidermal growth factor receptor
(EGFR)–mutated … (TKI) therapy for EGFR-mutated synchronous oligometastatic NSCLC and …

Machine learning-based radiomics signatures for EGFR and KRAS mutations prediction in non-small-cell lung cancer

NQK Le, QH Kha, VH Nguyen, YC Chen… - International journal of …, 2021 - mdpi.com
… strategy for specific individuals carrying mutations associated with improved sensitivity to …
of only 6 EGFR mutation carriers in the validation set compared with 12 EGFR wild-type carriers…

[HTML][HTML] Afatinib for the Treatment of Non-Small Cell Lung Cancer Harboring Uncommon EGFR Mutations: An Updated Database of 1023 Cases Brief Report

JCH Yang, M Schuler, S Popat, S Miura, K Park… - Frontiers in …, 2022 - frontiersin.org
… a database of 693 patients with NSCLC and uncommon EGFR mutations treated with
afatinib. Here, we provide an update of >1000 patients, with more data on specific mutations. …

The role of EGFR mutation as a prognostic factor in survival after diagnosis of brain metastasis in non-small cell lung cancer: a systematic review and meta-analysis

WY Li, TT Zhao, HM Xu, ZN Wang, YY Xu, Y Han… - BMC cancer, 2019 - Springer
… illustrated that EGFR mutations are significantly … EGFR mutations and OS for these patients
[20,21,22,23,24,25,26,27,28,29]. Two studies have even suggested that EGFR mutations may …

Epidemiological and clinical burden of EGFR Exon 20 insertion in advanced non-small cell lung cancer: A systematic literature review

H Burnett, H Emich, C Carroll, N Stapleton… - PLoS …, 2021 - journals.plos.org
… the prognostic impact of Exon 20ins were heterogeneous but highlighted poorer outcomes
in patients with Exon 20ins mutation compared with patients with other EGFR mutations and …

Mining whole-lung information by artificial intelligence for predicting EGFR genotype and targeted therapy response in lung cancer: a multicohort study

S Wang, H Yu, Y Gan, Z Wu, E Li, X Li, J Cao… - The Lancet Digital …, 2022 - thelancet.com
… We found 14 studies that used deep learning and CT imaging to predict EGFR mutation
status in patients with lung cancer. The largest dataset obtained so far included 914 patients in a …