Tepotinib plus gefitinib in patients with EGFR-mutant non-small-cell lung cancer with MET overexpression or MET amplification and acquired resistance to previous …
Background We evaluated the efficacy and safety of tepotinib, a potent and highly selective
oral MET inhibitor, plus gefitinib in patients with epidermal growth factor receptor (EGFR)-…
oral MET inhibitor, plus gefitinib in patients with epidermal growth factor receptor (EGFR)-…
[HTML][HTML] Patient-reported outcomes from FLAURA: osimertinib versus erlotinib or gefitinib in patients with EGFR-mutated advanced non-small-cell lung cancer
NB Leighl, N Karaseva, K Nakagawa, BC Cho… - … Journal of Cancer, 2020 - Elsevier
… The PRO analyses presented here show improvements in key lung cancer symptoms in both
… The overall burden of key lung cancer symptoms was low at baseline, with most patients in …
… The overall burden of key lung cancer symptoms was low at baseline, with most patients in …
Gefitinib alone versus gefitinib plus chemotherapy for non–small-cell lung cancer with mutated epidermal growth factor receptor: NEJ009 study
Y Hosomi, S Morita, S Sugawara, T Kato… - Journal of Clinical …, 2020 - ascopubs.org
… patients were randomly assigned to gefitinib (gefitinib 250 mg orally once every day) or GCP
regimen (gefitinib … by concurrent gefitinib and pemetrexed maintenance). In the GCP group, …
regimen (gefitinib … by concurrent gefitinib and pemetrexed maintenance). In the GCP group, …
[HTML][HTML] A phase III, randomized, open-label study of ASP8273 versus erlotinib or gefitinib in patients with advanced stage IIIB/IV non-small-cell lung cancer
… The current study examines the efficacy, safety, and tolerability of ASP8273 versus
erlotinib or gefitinib in patients with non-small-cell lung cancer (NSCLC) with activating EGFR …
erlotinib or gefitinib in patients with non-small-cell lung cancer (NSCLC) with activating EGFR …
Radiotherapy combined with gefitinib for patients with locally advanced non-small cell lung cancer who are unfit for surgery or concurrent chemoradiotherapy: a phase …
Z Fu, X Yang, W Wang, L Deng, T Zhang, N Bi… - Radiation …, 2020 - Springer
… For locally advanced lung cancer, there are no prospective studies that have … gefitinib
could improve the survival of patients with locally advanced EGFR-activating mutation lung …
could improve the survival of patients with locally advanced EGFR-activating mutation lung …
Gefitinib Versus Gefitinib Plus Pemetrexed and Carboplatin Chemotherapy in EGFR-Mutated Lung Cancer
… (†) Of 71 patients continuing on the gefitinib plus pemetrexed and carboplatin … , 47 patients
continue to receive both chemotherapy and gefitinib. Twenty-four patients have discontinued …
continue to receive both chemotherapy and gefitinib. Twenty-four patients have discontinued …
A phase Ib study of the highly selective MET-TKI savolitinib plus gefitinib in patients with EGFR-mutated, MET-amplified advanced non-small-cell lung cancer
JJ Yang, J Fang, YQ Shu, JH Chang, GY Chen… - Investigational New …, 2021 - Springer
… Chinese patients with … -in, patients received savolitinib 600 or 800 mg plus gefitinib 250 mg
orally once daily, and dose-limiting toxicities were recorded. In the expansion phase, patients …
orally once daily, and dose-limiting toxicities were recorded. In the expansion phase, patients …
Combination of gefitinib and olaparib versus gefitinib alone in EGFR mutant non-small-cell lung cancer (NSCLC): A multicenter, randomized phase II study (GOAL)
…, R Rosell, Spanish Lung Cancer Group - Lung Cancer, 2020 - Elsevier
… In the present study, no differences in PFS were seen among the patients receiving gefitinib
alone or those receiving gefitinib plus olaparib, even though a trend towards longer PFS …
alone or those receiving gefitinib plus olaparib, even though a trend towards longer PFS …
… vs gefitinib for patients with EGFR mutation-positive NSCLC (LUX-Lung 7): impact of afatinib dose adjustment and analysis of mode of initial progression for patients …
M Schuler, EH Tan, K O'Byrne, L Zhang… - Journal of cancer …, 2019 - Springer
… In the randomized phase IIb LUX-Lung 7 trial, afatinib significantly … gefitinib in patients with
treatment-naïve epidermal growth factor receptor mutation-positive non-small cell lung cancer…
treatment-naïve epidermal growth factor receptor mutation-positive non-small cell lung cancer…
[HTML][HTML] Optimizing the sequencing of tyrosine kinase inhibitors (TKIs) in epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer …
ACZ Gelatti, A Drilon, FC Santini - Lung cancer, 2019 - Elsevier
… 20 of 114 patients did not receive any subsequent regimens after first-line gefitinib due to a
poor performance status, interstitial lung disease, exacerbation of co-morbidities, and patient …
poor performance status, interstitial lung disease, exacerbation of co-morbidities, and patient …
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