… mammalian development. We also discuss new insights gained into the patterning of DNA
methylation … current views of the diverse functions of DNA methylation in genetic diseases. …

… DNA Methylation—the addition of a methyl group to the 5-position of cytosine, forming 5-…
of DNA modification in many, but not all, eukaryotic organisms. In mammals, DNA methylation …

… be incorporated into robust epigenetic codes. Here, we summarize the current understanding
of the distinct DNA methylation landscapes that emerge over the mammalian lifespan and …

… profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the … pan-mammalian
clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium…

… Since such pan-tissue epigenetic clocks have been … -mammalian clocks that measure age
in all mammalian species. To address this, we generated data using 11,754 methylation arrays…

… DNA methylation profiles closely parallels that of genetics through evolution. Our results
demonstrate that DNA methylation … The publicly available data from our Mammalian Methylation …

… Lastly, we summarize recent understanding of the regulation of DNA methylation dynamics
in mammalian germ lines and early embryos with a focus on both mice and humans. …

… , many species display DNA methylation (5–7). In mammals, which will be the focus of
this review, DNA methylation is essential for embryonic development and cellular function (8–10). …

… of DNA methylation has evolved from one in which methylation … a braoder perspective where
DNA methylation is dynamically … accepted that DNA methylation is essential in mammalian …

… Fortunately, the recent development of targeted tools for manipulating DNA methylation … of
DNA methylation in the mammalian genome and explore the current state of DNA methylation-…