The methyl-CpG–Binding domain 2 and 3 proteins and formation of the nucleosome remodeling and deacetylase complex

G Leighton, DC Williams Jr - Journal of molecular biology, 2020 - Elsevier
… In this review, we discuss the formation of the NuRD complex focusing on the structures
of the different components, the critical role provided by MBD2 or MBD3, how differences in …

Stabilization of VEGF i-motif structure by CpG methylation

K Kimura, D Oshikawa, K Ikebukuro… - … and Biophysical Research …, 2022 - Elsevier
structure is stabilized by CpG methylation. In this study, the effect of CpG methylation on the
stability of the VEGF i-motif structure … contains four cytosines on CpG sites, and three of the …

Structural basis for effects of CpA modifications on C/EBPβ binding of DNA

J Yang, JR Horton, D Wang, R Ren, J Li… - Nucleic acids …, 2019 - academic.oup.com
… To understand the effects of both CpG and CpA modification on a … The protein components
of the two structures are highly … methyl specific recognition in the higher resolution structure of …

[HTML][HTML] DNA methylation: Precise modulation of chromatin structure and dynamics

S Li, Y Peng, AR Panchenko - Current opinion in structural biology, 2022 - Elsevier
… with methyl-binding domains that recognize methylated CpG … their influence on nucleosomal
structure and dynamics. DNA … component of base stacking, the addition of methyl groups …

[HTML][HTML] Densely methylated DNA traps Methyl-CpG–binding domain protein 2 but permits free diffusion by Methyl-CpG–binding domain protein 3

GO Leighton, EM Irvin, P Kaur, M Liu, C You… - Journal of Biological …, 2022 - ASBMB
… In the current work, we focus on the structure and dynamics of the MBD2 and MBD3
proteins. These two highly homologous proteins arose from a duplication of the ancestral MBD …

Structural dynamics of DNA depending on methylation pattern

T Kameda, MM Suzuki, A Awazu, Y Togashi - Physical Review E, 2021 - APS
… A methyl group (−CH3) binds to the cytosine base in a CpGstructural variation of the DNA
model was characterized by the ratios of the square root of the three principal components of …

Sequence determinants, function, and evolution of CpG islands

A Angeloni, O Bogdanovic - Biochemical Society Transactions, 2021 - portlandpress.com
… DNA methylation (5mC) and methyl-CpG binding proteins (MBDs)… provides rigidity to the
domain structure. Binding is mediated … diverse readers including components of COMPASS and …

[HTML][HTML] Complete profiling of methyl-CpG-binding domains for combinations of cytosine modifications at CpG dinucleotides reveals differential read-out in normal and …

BC Buchmuller, B Kosel, D Summerer - Scientific Reports, 2020 - nature.com
… hMBD3, a key component of the Mi-2/… structure-function-relationships reveal markedly
different abilities of the human core family MBDs to discriminate between cognate mC/mC CpG

How methyl–sugar interactions determine DNA structure and flexibility

K Liebl, M Zacharias - Nucleic acids research, 2019 - academic.oup.com
… allow switching on or off interactions with the methyl groups in several DNA sequences,
we … methyl groups and DNA backbone fine structure. Whereas methyl-solvent and methyl–…

A methyl-TROSY approach for NMR studies of high-molecular-weight DNA with application to the nucleosome core particle

G Abramov, A Velyvis, E Rennella… - Proceedings of the …, 2020 - National Acad Sciences
… to study structural and motional properties of both the DNA and the protein components in
… mononucleosomes establish that CpG methylation does not perturb the structure of the NCP …