[HTML][HTML] Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers
… increasing density of methylation, but whether density itself … have higher levels of gene
promoter methylation compared with HPV-… of transcriptional repression from DNA methylation at …
promoter methylation compared with HPV-… of transcriptional repression from DNA methylation at …
[HTML][HTML] The concurrence of DNA methylation and demethylation is associated with transcription regulation
… Besides sequencing depth, CpG density also affects the correlations between methylation
… three groups of genes demonstrate more significant transcriptional repression (ie, smaller p-…
… three groups of genes demonstrate more significant transcriptional repression (ie, smaller p-…
Sensitivity of transcription factors to DNA methylation
… limited to regions with high mCpG densities, often located at CpG-island gene promoters [79]. …
act as a transcriptional repressor, although the functions of DNA methylation still remain to …
act as a transcriptional repressor, although the functions of DNA methylation still remain to …
[HTML][HTML] Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability
… transcriptional repression that was linked to methylation … density was different across
promoter-DMRs, and discovered that downregulated genes feature higher median CpG density in …
promoter-DMRs, and discovered that downregulated genes feature higher median CpG density in …
Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic
J Cholewa-Waclaw, R Shah, S Webb… - Proceedings of the …, 2019 - National Acad Sciences
… expression changes and DNA methylation that otherwise might … according to methylation
density, considering gene bodies … the linear relationship between gene repression and MeCP2 …
density, considering gene bodies … the linear relationship between gene repression and MeCP2 …
CG dinucleotides enhance promoter activity independent of DNA methylation
… DNA methylation is generally repressive at high CpG density … It is further tempting to speculate
that methylation of CpGs in … account for the transcriptional repression of methylated CGIs. …
that methylation of CpGs in … account for the transcriptional repression of methylated CGIs. …
[HTML][HTML] H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress
… methylation on genes is coupled with transcriptional activity 27 ; however, our results suggest
that transcription and H3K4 methylation … Then, we repressed its transcription just before …
that transcription and H3K4 methylation … Then, we repressed its transcription just before …
Transcriptional alterations in glioma result primarily from DNA methylation–independent mechanisms
E Le Boiteux, A Fogli, M Müller-Barthélémy… - Genome …, 2019 - genome.cshlp.org
… (B) Heatmap showing CpG sites density and their mean methylation level in a ±2 kb window
… To understand how Meth+/Exp− and No Meth/Exp− genes were transcriptionally repressed, …
… To understand how Meth+/Exp− and No Meth/Exp− genes were transcriptionally repressed, …
DNA methylation as a transcriptional regulator of the immune system
… that allows DNA methylation density assessment and fragment … regions of high CpG density
when compared with MeDIP. … cells acquired repressive de novo DNA methylation at genes …
when compared with MeDIP. … cells acquired repressive de novo DNA methylation at genes …
Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors
M Cusack, HW King, P Spingardi, BM Kessler… - Genome …, 2020 - genome.cshlp.org
… is capable of altering TF-DNA interactions and recruiting HDACs, how these distinct
mechanisms contribute to DNA methylation-dependent repression at the genome scale remains …
mechanisms contribute to DNA methylation-dependent repression at the genome scale remains …
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- chromatin dysregulation transcriptional repression
- temporal uncoupling transcriptional repression
- dna methylation transcription factors
- dna methylation gene regulation
- transcription replication conflicts h3k4 methylation
- promoter dna methylation transcriptional responses
- dna methylation gene body
- dna methylation transcriptional alterations
- effects of cytosine methylation transcription factor
- methylation and demethylation genes cells
- dna methylome transcriptional repression
- active genes h3k4 methylation