[HTML][HTML] Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers

M Ando, Y Saito, G Xu, NQ Bui… - Nature …, 2019 - nature.com
… increasing density of methylation, but whether density itself … have higher levels of gene
promoter methylation compared with HPV-… of transcriptional repression from DNA methylation at …

[HTML][HTML] The concurrence of DNA methylation and demethylation is associated with transcription regulation

J Shi, J Xu, YE Chen, JS Li, Y Cui, L Shen, JJ Li… - Nature …, 2021 - nature.com
… Besides sequencing depth, CpG density also affects the correlations between methylation
… three groups of genes demonstrate more significant transcriptional repression (ie, smaller p-…

Sensitivity of transcription factors to DNA methylation

É Héberlé, AF Bardet - Essays in biochemistry, 2019 - portlandpress.com
… limited to regions with high mCpG densities, often located at CpG-island gene promoters [79]. …
act as a transcriptional repressor, although the functions of DNA methylation still remain to …

[HTML][HTML] Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability

A de Mendoza, TV Nguyen, E Ford, D Poppe… - Genome Biology, 2022 - Springer
transcriptional repression that was linked to methylationdensity was different across
promoter-DMRs, and discovered that downregulated genes feature higher median CpG density in …

Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic

J Cholewa-Waclaw, R Shah, S Webb… - Proceedings of the …, 2019 - National Acad Sciences
… expression changes and DNA methylation that otherwise might … according to methylation
density, considering gene bodies … the linear relationship between gene repression and MeCP2 …

CG dinucleotides enhance promoter activity independent of DNA methylation

D Hartl, AR Krebs, RS Grand, T Baubec, L Isbel… - Genome …, 2019 - genome.cshlp.org
… DNA methylation is generally repressive at high CpG density … It is further tempting to speculate
that methylation of CpGs in … account for the transcriptional repression of methylated CGIs. …

[HTML][HTML] H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress

SY Chong, S Cutler, JJ Lin, CH Tsai, HK Tsai… - Nature …, 2020 - nature.com
methylation on genes is coupled with transcriptional activity 27 ; however, our results suggest
that transcription and H3K4 methylation … Then, we repressed its transcription just before …

Transcriptional alterations in glioma result primarily from DNA methylation–independent mechanisms

E Le Boiteux, A Fogli, M Müller-Barthélémy… - Genome …, 2019 - genome.cshlp.org
… (B) Heatmap showing CpG sites density and their mean methylation level in a ±2 kb window
… To understand how Meth+/Exp− and No Meth/Exp− genes were transcriptionally repressed, …

DNA methylation as a transcriptional regulator of the immune system

L Morales-Nebreda, FS McLafferty, BD Singer - Translational Research, 2019 - Elsevier
… that allows DNA methylation density assessment and fragment … regions of high CpG density
when compared with MeDIP. … cells acquired repressive de novo DNA methylation at genes …

Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors

M Cusack, HW King, P Spingardi, BM Kessler… - Genome …, 2020 - genome.cshlp.org
… is capable of altering TF-DNA interactions and recruiting HDACs, how these distinct
mechanisms contribute to DNA methylation-dependent repression at the genome scale remains …