… protein 1 (DMP1) by downregulating miR-145 and miR-143. … of miR145, thereby releasing
the expression of target genes … KLF4 and OSX upregulated the odontoblast marker genes …

… (OCT4, SOX2, and KLF4). Therefore, the … increased expression of odontoblastic differentiation
markers. miR-488 … of miR-145 and miR-143 promotes odontogenic differentiation as …

… Our findings first revealed that miR-143-3p can regulate 75 differentiation of … miR-145 and
miR-143 regulate odontoblast 420 differentiation through targeting Klf4 and Osx genes in a …

… into odontoblasts, HDAC3 primarily interacts with KLF4 at the … have revealed that miR-143
and miR-145 are significantly … form a negative regulatory feedback loop with KLF4 to inhibit …

… of DPSCs by targeting KLF4 and OSX [39]. … of Osterix (Osx), suggesting that MALAT1-miR-143-Osx
could be an … in this study, which show that miR-145 is overexpressed in the course of …

… companion to the downstream target genes to positively or negatively regulate … that, during
odontoblast differentiation, klf4 is posttranscriptionally regulated by mir‐143 and mir‐145, ( 21 …

… miR-143 and miR-145 can repress osteogenic differentiation through the regulation of OSX
… feedback loop with Kruppel-like factor 4 (KLF4) and OSX in odontoblasts [30]. DLX5 is a bone…

… and Osx shRNA were used to mimic osteogenic differentiation in … vivo initiation of odontoblast
differentiation down-regulates the … the expression of Klf4 and Osterix target genes. These …

… to validate the target and downstream regulatory genes of miR-… cells polarize and differentiate
into odontoblasts to secrete dentin … MiR-143-5p was reported to regulate the odontogenic …

… expression of odontoblast proteins, Runx2, Osterix (Osx), and … Mechanistically, KLF4
promotes odontoblastic differentiation … , downregulation of miR-143 and miR-145 led to elevated …