Intracellular Signaling Mechanisms Involved in the Biological Effects of the Xanthophyll Carotenoid Astaxanthin to Prevent the Photo‐aging of the Skin in a Reactive …

G Imokawa - Photochemistry and Photobiology, 2019 - Wiley Online Library
… ) and microphthalmia-associated transcription factor (MITF) … the activation of p38 MAPK or
the signaling pathways of the … of CREB together with other transcription factors such as SOX10, …

Epithelial-Mesenchymal Transition: Molecular Mechanisms of Retinal Pigment Epithelial Cell Activation

AV Kuznetsova - Russian Journal of Developmental Biology, 2022 - Springer
… ERK1/2 cascades are stimulated mainly by growth factors, whereas JNK and p38 MAPKs
kinase (JAK)/STAT signaling pathway, the transcription factor STAT3, and a key activator of …

[HTML][HTML] Decursin prevents melanogenesis by suppressing MITF expression through the regulation of PKA/CREB, MAPKs, and PI3K/Akt/GSK-3β cascades

H Choi, JH Yoon, K Youn, M Jun - Biomedicine & Pharmacotherapy, 2022 - Elsevier
transcription factor in melanogenesis. Further, decursin exerted anti-melanogenic effects by
downregulating the p38 signaling pathwayMicrophthalmia-associated transcription factor (…

Yohimbine hydrochloride inhibits skin melanin synthesis by regulating wnt/β-catenin and p38/MAPK signal pathways

T Fu, X Qin, Y Ma, X Yuan, S Wu, X Ye… - Journal of Dermatological …, 2022 - Elsevier
… The expression of microphthalmia-associated transcription factor (MITF), tyrosinase and
the activities of Wnt/β-catenin and p38/MAPK signal pathways were determined by RT-qPCR, …

c-Jun N-terminal kinase 1 (JNK1) phosphorylates OTX2 transcription factor that regulates early retinal development

MJ An, HM Lee, CH Kim, GS Shin, AR Jo, JY Kim… - Genes & Genomics, 2023 - Springer
… and microphthalmia. However, the regulatory mechanisms of OTX2 are poorly identified. …
with its target transcription factors. JNK1 is involved in various biological pathways by being …

Lincomycin induces melanogenesis through the activation of MITF via p38 MAPK, AKT, and PKA signaling pathways

MS Lee, YC Chung, SH Moon… - Journal of Applied …, 2021 - koreascience.kr
Microphthalmia-associated transcription factor (MITF) plays … kinases (MAPK) family, which
consist of p38 MAPK, extracellular … Recent studies have reported that the activation of p38 and …

Small Noncoding RNA in Regulation of Differentiation of Retinal Pigment Epithelium

AV Kuznetsova, LA Rzhanova… - Russian Journal of …, 2021 - Springer
… kinase (MAPK) signals has … MAPK pathway causes death of retinal cells (Van Dijk et al.,
2016). These observations highlight the need for tight regulation of MAPK and related pathways

Insights into the regulatory molecules involved in glaucoma pathogenesis

H Moazzeni, M Khani, E Elahi - American Journal of Medical …, 2020 - Wiley Online Library
… protein-1 (AP1) transcription factor family that regulates the expression … MAP kinase family.
MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling

[HTML][HTML] microRNAs in the Regulation of Melanogenesis

Y Hushcha, I Blo, L Oton-Gonzalez, GD Mauro… - International Journal of …, 2021 - mdpi.com
microphthalmia-associated transcription factor (MITF), the key … by several kinases such as
MAPK, p38, ribosomal S6 kinase (… The MAPK signaling pathway can be activated by several …

Molecular Biology of Iris

KT Moazed, KT Moazed - The Iris: Understanding the Essentials, 2020 - Springer
… , signaling pathways and nuclear transcription factors. From … microphthalmia-associated
transcription factor (MITF), a key … several signaling molecules after Nrf2 via CREB, p38 MAPK