microRNA‐based diagnostic and therapeutic applications in cancer medicine

LF Sempere, AS Azmi, A Moore - Wiley Interdisciplinary …, 2021 - Wiley Online Library
… , and developed a battery of viral and nonviral delivery … are a limited number of
microRNA-based applications that have … into viable microRNA-based clinical tools for cancer

A comprehensive review of cancer MicroRNA therapeutic delivery strategies

A Forterre, H Komuro, S Aminova, M Harada - Cancers, 2020 - mdpi.com
… significant hurdles in therapeutic miRNA usage are the stability and the delivery system. In
… of therapeutic miRNA delivery systems that includes virus-based delivery, non-viral delivery (…

Challenges identifying efficacious miRNA therapeutics for cancer

M Segal, FJ Slack - Expert opinion on drug discovery, 2020 - Taylor & Francis
miRNA therapeutics will have a major part in cancer therapy in the future. Specifically,
personalized cancer medicine can be accomplished by constructing the unique miRNA mimic or …

MicroRNA delivery through nanoparticles

SWL Lee, C Paoletti, M Campisi, T Osaki… - Journal of Controlled …, 2019 - Elsevier
… of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and
… highlighted to underline their therapeutic potential for effective and personalized medicine. …

MicroRNA replacement therapy in cancer

H Mollaei, R Safaralizadeh… - Journal of cellular …, 2019 - Wiley Online Library
… The systemic miRNA delivery strategy is a significant progress to overcome the … of miRNA
delivery in vivo and elevate the impact of cancer therapy. Up to now, different systemic delivery

Recent advances in miRNA delivery systems

I Dasgupta, A Chatterjee - Methods and protocols, 2021 - mdpi.com
… Nevertheless, RV-mediated miRNA delivery has been shown to be promising in regenerative
medicine. For example, heightened expression of miR-138 in murine embryonic fibroblasts …

Recent progress in microRNA-based delivery systems for the treatment of human disease

Y Fu, J Chen, Z Huang - ExRNA, 2019 - Springer
… Here, we introduce four widely used viral vectors for miRNA delivery including
adenovirus vectors, adeno-associated virus vectors, retroviral vectors, and lentivirus vectors. …

Advances in the discovery of microRNA-based anticancer therapeutics: latest tools and developments

KKW To, W Fong, CWS Tong, M Wu… - Expert opinion on …, 2020 - Taylor & Francis
… been applied to correct the dysregulated miRNA in cancer cells. The authors also …
miRNA-based therapeutic agents. Expert opinion: Application of miRNA-based therapeutics for …

Strategies to modulate microRNA functions for the treatment of cancer or organ injury

TJ Lee, X Yuan, K Kerr, JY Yoo, DH Kim, B Kaur… - Pharmacological …, 2020 - ASPET
… inhibitors and highlights current progress in miRNA-… in miRNA delivery, we believe that
additional therapeutic approaches to modulate miRNA function will soon enter routine medical

Nanoparticle-based delivery of tumor suppressor microRNA for cancer therapy

CP O'Neill, RM Dwyer - Cells, 2020 - mdpi.com
… MiR-34a encapsulated in a liposomal formulation, coined MRX34, was tested as a viable TS
miRNA delivery therapy in a preclinical liver cancer study. After IV injection of MRX34 in two …