Key inflammatory mechanisms underlying heart failure

C Riehle, J Bauersachs - Herz, 2019 - Springer
… and increased expression of endothelial inflammatory adhesion molecules [39]. Even
though the underlying molecular mechanisms require further investigation, these observations …

The septic heart: current understanding of molecular mechanisms and clinical implications

L Martin, M Derwall, S Al Zoubi, E Zechendorf… - Chest, 2019 - Elsevier
… , some markers of heart failure, such as the N-terminal pro-B-type natriuretic peptide (NT-pro-BNP),
have been suggested to facilitate the diagnosis of septic cardiomyopathy 58 (area …

Cellular and molecular pathobiology of heart failure with preserved ejection fraction

S Mishra, DA Kass - Nature Reviews Cardiology, 2021 - nature.com
… In this Review, we focus on the cellular and molecular mechanisms of HFpEF as currently
understood from the available experimental and clinical data. The figures display the …

Molecular mechanisms of arrhythmogenic cardiomyopathy

KM Austin, MA Trembley, SF Chandler… - Nature Reviews …, 2019 - nature.com
… The development of heart failure with associated symptoms typically occurs later in the
disease process, although it can be an initial manifestation in a subset of patients. Features …

Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease

A Li, M Gao, B Liu, Y Qin, L Chen, H Liu, H Wu… - Cell death & …, 2022 - nature.com
… Dysfunctional mitochondria accumulation is involved in the pathophysiology of cardiovascular
diseases, such as myocardial infarction, cardiomyopathy and heart failure. This review …

[HTML][HTML] Pathophysiology of heart failure

RHG Schwinger - Cardiovascular diagnosis and therapy, 2021 - ncbi.nlm.nih.gov
… initiate heart failure. Identification of the pathophysiological mechanism leading to heart failure
… The clinical severity of heart failure is graded according the New York Heart Association (…

Oxidative stress as a mechanism for functional alterations in cardiac hypertrophy and heart failure

AK Shah, SK Bhullar, V Elimban, NS Dhalla - Antioxidants, 2021 - mdpi.com
… Over the past 30 years various types of pathological stimuli have been shown to involve
different signal transduction pathways as well as cellular and molecular mechanisms for the …

Targeting age-related pathways in heart failure

H Li, MH Hastings, J Rhee, LE Trager, JD Roh… - Circulation …, 2020 - Am Heart Assoc
… and function leads to increased susceptibility to heart failure. The need for … the molecular
mechanisms of age-related heart failure and … A major risk factor for heart failure (HF) and overall …

Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities

NG Frangogiannis - Molecular aspects of medicine, 2019 - Elsevier
… biological mechanisms, study of the functional consequences of fibrotic changes on the
myocardium, and identification of heart failure patient subsets with overactive fibrotic responses. …

The molecular mechanisms of iron metabolism and its role in cardiac dysfunction and cardioprotection

T Ravingerová, L Kindernay, M Barteková… - … journal of molecular …, 2020 - mdpi.com
… Iron deficiency is frequently present in heart failure patients with reduced ejection fraction …
The current knowledge of the pathophysiology of iron deficiency in heart failure, its clinical …