… Therefore, we hypothesized that the motor learning deficits in cerebellar KO mice originate
from the loss of Mecp2 in excitatory granule cells, inhibitory Purkinje cells, and/or molecular …

… skills require plasticity in the motor cortex and striatum, two key motor regions of the … motor
learning to form a memory engram remains unknown. Here, we train mice on a motor learning …

… To investigate the relationship between increased spine formation, spine survival, and
enhanced motor learning in PirB −/− mice, a longitudinal experiment that combined chronic in …

… Reduced expression of cortical BDNF in 3-month-old mice results in impaired motor learning
while space memory is preserved. These findings suggest that activity regulates BDNF …

… motor cortex during motor learning in transgenic mice with a subtle impairment of their myelin.
This deficit in myelin impaired motor learning… axon terminals restored motor learning. Thus…

… We trained mice on a forelimb reaching motor task and repeatedly imaged surface expression
levels of the AMPAR subunit GluA1 on the same dendritic segments of layer 5 neurons in …

… By contrast, optostimulation of granule neurons in lobule IX as the CS or of distinct types
of control mice failed to induce motor learning (Fig. 1j, Extended Data Fig. 2c, d). …

… Here, we reveal that mice … motor learning without showing gross motor deficits. Using in
vivo two-photon imaging in awake mice, we find that layer 2/3 excitatory neurons in the motor …

… To control for motor activity rather than motor learning, mice were trained pre-cuprizone
administration and rehearsed the forelimb reach task post-cuprizone treatment (Extended Data …

… -activated neurons and their associated axons were permanently labeled with tdTomato
only in mice that received both motor learning and 4-OHT administration. Untrained …