Pathogenic mechanisms underlying idiopathic pulmonary fibrosis

BJ Moss, SW Ryter, IO Rosas - Annual Review of Pathology …, 2022 - annualreviews.org
… The pathologic features of honeycombing, traction bronchiectasis, and fibroblastic foci are
frequently observed in IPF and represent remodeling of the normal lung architecture. Once the …

Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis

T Parimon, C Yao, BR Stripp, PW Noble… - International journal of …, 2020 - mdpi.com
… to their normal functional capacity and development of a pro-fibrotic phenotype has been
demonstrated to contribute to the development of idiopathic pulmonary fibrosis (… of lung fibrosis. …

Idiopathic pulmonary fibrosis: Current and future treatment

DS Glass, D Grossfeld, HA Renna… - The clinical …, 2022 - Wiley Online Library
… areas of fibrosis with hyperplastic alveolar epithelial cells adjacent to these fibroblastic foci,
alternating with less affected areas of normal or nearly normal lung tissue. Lung architecture …

Idiopathic pulmonary fibrosis: an update on pathogenesis

Q Mei, Z Liu, H Zuo, Z Yang, J Qu - Frontiers in pharmacology, 2022 - frontiersin.org
… Compared with normal lungs, the subpopulation of macrophages that highly express SPP1
and MERTK (SPP1hi) and NTN1 (laminin-like protein netrin-1) increased significantly in IPF …

Epithelial–mesenchymal transition in the pathogenesis of idiopathic pulmonary fibrosis

F Salton, MC Volpe, M Confalonieri - Medicina, 2019 - mdpi.com
pulmonary fibrosis (IPF) is a serious disease of the lung, … cases of pulmonary fibrosis exhibit
mutations in genes normally … progenitor cells in normal lung and allow regeneration of the …

The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis

M Selman, A Pardo - Cellular signalling, 2020 - Elsevier
… Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and devastating … lung
disease of unknown etiology, where the normal lung architecture is lost and replaced by fibrotic

Fatal pulmonary fibrosis: a post-COVID-19 autopsy case

HF Schwensen, LK Borreschmidt… - Journal of clinical …, 2021 - jcp.bmj.com
… The patient had no history of pulmonary illnesses prior to infection and had a normal CT scan
of the lungs with no evidence of pulmonary fibrosis just 2 months before COVID-19. During …

Single-cell reconstruction of human basal cell diversity in normal and idiopathic pulmonary fibrosis lungs

G Carraro, A Mulay, C Yao, T Mizuno… - American journal of …, 2020 - atsjournals.org
… Declining lung function results from scarring and remodeling … of single cells from normal
human lungs and lung tissue of … distinct states in the normal lung, including multipotent and …

[PDF][PDF] The management of pulmonary fibrosis in COVID-19

CM Rumende, EC Susanto, TP Sitorus - Acta Med Indones, 2021 - academia.edu
… the normal lung architecture. There are risk factor for pulmonary fibrosis namely advanced
age… severe ARDS infection, mechanical ventilation due to ventilator-induced lung injury, …

COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts

AE John, C Joseph, G Jenkins… - Immunological reviews, 2021 - Wiley Online Library
… exhibiting significant lung abnormalities postinfection … pulmonary fibrosis with relatively
normal lung function as with SARS or MERS, or go on to develop progressive pulmonary fibrosis, …