Ruscogenin attenuates sepsis-induced acute lung injury and pulmonary endothelial barrier dysfunction via TLR4/Src/p120-catenin/VE-cadherin signalling pathway

Y Wang, L Xue, Y Wu, J Zhang, Y Dai… - Journal of Pharmacy …, 2021 - academic.oup.com
… of VE-cadherin and maintains endothelial barrier function. [41] Decreased expression of
pulmonary VE-cadherin and p120-catenin were observed in animal models of sepsis-induced …

[HTML][HTML] Protocadherin 20 maintains intestinal barrier function to protect against Crohn's disease by targeting ATF6

S Huang, Z Xie, J Han, H Wang, G Yang, M Li, G Zhou… - Genome Biology, 2023 - Springer
… In this study, we describe a critical role for PCDH20 in maintaining intestinal homeostasis.
Intestinal-… However, we detected only the T310 and S288 phosphosites of p120-catenin as no …

[HTML][HTML] E-cadherin beyond structure: a signaling hub in colon homeostasis and disease

AC Daulagala, MC Bridges, A Kourtidis - International journal of …, 2019 - mdpi.com
… , namely p120 catenin (p120), α-catenin, and β-catenin [2]. Nectin is another important cell-cell
… diabetes and hyperglycemia negatively impact intestinal barrier function, which, in turn, …

Trans-compartmental regulation of tight junction barrier function

AN Naser, Q Lu, YH Chen - Tissue Barriers, 2023 - Taylor & Francis
… , demonstrating disruption of the intestinal barrier function. This study highlights the essential
role of p120 ctn in maintaining TJ barrier function and intestinal homeostasis. Citation34 …

[HTML][HTML] EpCAM is essential for maintenance of the small intestinal epithelium architecture via regulation of the expression and localization of proteins that compose …

G Chen, Y Yang, W Liu, L Huang… - International …, 2021 - spandidos-publications.com
intestines, and is essential for maintaining the homeostasis of the intestinal epithelium…
EpCAM protein is localized at tight junctions and the basolateral membrane of the intestinal

[HTML][HTML] Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases

LR Lessey, SC Robinson, R Chaudhary… - Frontiers in Cell and …, 2022 - frontiersin.org
… cofactors (α, β, γ, and p120-catenin). One organ where … essential for normal intestinal
homeostasis, studies from our lab and others have explored Kaiso’s role in the mammalian intestine

P120-catenin regulates pulmonary fibrosis and TGF-β induced lung fibroblast differentiation

Y Zhang, H Jiao, Y Wu, X Sun - Life sciences, 2019 - Elsevier
P120-catenin (P120) was known to function in adhesion between cells and signal transduction
in many types of cells. In this study, we investigated the expression and role of P120 in …

p120-Catenin suppresses NLRP3 inflammasome activation in macrophages

P Kanmani, HEH Elkafas, M Ghazal… - … of Physiology-Lung …, 2023 - journals.physiology.org
… Here we investigated the role of p120-catenin expression in … Depletion of p120-catenin
in murine bone marrow-derived … Coimmunoprecipitation analysis showed that p120-catenin

[HTML][HTML] Differential expression of p120-catenin 1 and 3 isoforms in epithelial tissues

JH Venhuizen, S Sommer, PN Span, P Friedl… - Scientific reports, 2019 - nature.com
p120-catenin is essential for maintenance of barrier function and intestinal homeostasis
in mice. J Clin Invest 120, 1824–1835, https://doi.org/10.1172/JCI41414 (2010). …

ROCK1 inhibitor stabilizes E-cadherin and improves barrier function in experimental necrotizing enterocolitis

C Buonpane, C Yuan, D Wood… - … -Gastrointestinal …, 2020 - journals.physiology.org
maintaining normal barrier homeostasis. Rho-associated protein kinase-1 (ROCK1) is a kinase
that regulates the E-cadherin complex, and p120-catenin is … gastrointestinal homeostasis. …