… nuclear localisation and stability of CDKN1A/p21 [14]. Human interacting proteins of … of
mesenchymal markers, suggesting that CDKN1A/p21 is a negative regulator of EMT, and may …

… Reversible protein phosphorylation by diverse kinases serves as an additional posttranslational
mechanism controlling p21′s function, localization, binding partners, stability and …

… The p21 CDKN1A protein is an important player in the maintenance of genome stability
through … In the DNA damage response, p21 interacts with specific proteins to integrate cell-cycle …

… Following p53 activation, transcription of p21/CDKN1A is strongly induced as a direct target
… Thus, p27 stabilization will cause hypophosphorylation of p130 and subsequent DREAM …

… p53, p21 WAF/CDKN1A is a major negative regulator of cell cycle progression and we observed
increased in p21 expression by p53. … p53 expression by controlling protein stability, and …

… effects, which add a novel level of complexity to the biological roles of p21 Cip1/Waf1 . … Our
data show that p53 stabilization cannot explain the expression dynamics of Cdkn1a variants …

… of p53 and p73, we generated stable HCT116 cell lines with either single loss of … of p53/p73-p21
CIP1 and mitotic defects leading to W-CIN, we re-expressed CDKN1A in cells with p53/…

… In addition to this, the fact that transient or stable KO of CDKN1A/P21 recapitulates the
altered replication dynamics of Trp53-deficient cells strongly suggests that loss of …

… of TP53 and p21 (CDKN1A) polymorphisms (p53 72 G > C—rs1042522; p53 PIN3—rs17878362;
p21 31 C > A—rs1801270; p21 70 C … By altering mRNA stability and inducing its faster …

… p21 and its master regulator p53 behaves reciprocally at the mRNA and protein level (Figure
1A,B). p53 … The first trimester-derived HTR cell line displayed a strong p53 and a lesser p21 …