… neural stem cell function to in vitro cortical neurogenesis, we show that p53 aids in proper
neural stem cell … function. Taken together, our 2D and 3D models derived from human iPS …

… In addition, the roles of p53 in cellular metabolism might also contribute to genomic stability
of … the roles of p53 in PSCs will be a prerequisite for developing safe PSC-based cell therapy. …

… neuronal lineage, from neural stem/progenitor cells to mature neurons, and is associated with
the dynamics of neuron-… -dependent/Cyclin D1/pRb signaling pathway as well as via a p53-…

… stem cells (GSCs) (5–7). Compelling evidence from the last decade suggests that GSCs
may arise from neural stem cells (… Loss of function of p53 changes the behavior of type B and …

… adult neural stem cells 24,29,30 , showed increased expression in mouse TG neurons
after inoculation with p53 null OCSCC cells (Fig. 5a). In line with the neo-neuron adrenergic …

… as cells progress from neural stem cells (NSCs) through to neural progenitor cells (NPCs) …
During embryonic neurogenesis (proliferation and differentiation phases), cells begin to rely …

… A major challenge comes from the need to focus such studies on primitive hematopoietic
stem cells (HSCs), a small fraction of the cells harvested by CD34 immunoselection. Whereas …

… embryonic stem cells and differentiating neural progenitor cells. … pathway was not detected
in our RNA-seq analyses, p53 is likely … of UTX and 53BP1 cause stem cell defects, leading to …

… Defects in RNA processing have also been linked to p53-dependent microcephaly. In mice,
heterozygous deletion of Eif4a3 or Rbm8a in neural progenitor cells triggers p53 activation …

… Using patient cells carrying POLG mutations, we generated iPSCs and then neural stem
cells. These neural precursors manifested a phenotype that faithfully replicated the molecular …