… have provided strong evidence on the role of PI3K/AKT/mTOR pathway in PDAC, clinical …
PI3K/AKT/mTOR pathway could provide valuable assets for treatment of pancreatic cancer …

… pancreatic cancer patients. In this review, we focus on PI3K/AKT/mTOR inhibitors that have
shown great anti-tumor potential in studies performed on xenograft models and pancreatic …

… Akt via … Akt phosphorylation and inhibits the transcription of PI3K, reducing its activation.
These results suggest that LAMB3 promotes tumor invasion via Akt activation through the PI3K …

… the PI3K-Akt signaling pathway and promotes pancreatic cancer growth in vivo To determine
whether IGF2BP2 promotes pancreatic cancer cell growth via the PI3K-Akt pathway in vivo …

… Uro A downregulated the oncogenic PI3K/AKT/mTOR signaling … tumor growth in both tumor
xenografts and genetically engineered mouse models in vivo by not only disrupting PI3K/AKT …

… increased PI3k/AKT… PI3K/Akt/mTOR cascade in human pancreatic cancer stem cells [35].
Accordingly, our results showed that autophagy was negatively regulated by the RAGE/PI3K/Akt…

… , and could activate PI3K/Akt pathway by interacting with the SH3 domain of PI3K regulatory
… PAK4 and PI3K/Akt pathway. Western blot analysis showed that the levels of PAK4, p-Akt, p-…

… Carboxypeptidase A4 (CPA4), as a novel tumor biomarker, is prevalently observed in various
cancers. However, the potential role of CPA4 in pancreatic cancer (PC), to our knowledge, …

… of PI3K/AKT/GSK signalling. The present study demonstrated NGF/TrkA promoted the PC
cell proliferation and invasion in the co-culture system by the activation of the PI3K/AKT/GSK …

… expression and activity of the PI3K and AKT are upregulated in pancreatic cancer cells, which
is … that the PI3K/AKT signaling pathway is a key regulatory pathway not only in pancreatic …