[HTML][HTML] … iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and …

JM Oh, BC Ahn - Theranostics, 2021 - ncbi.nlm.nih.gov
The advanced, metastatic differentiated thyroid cancers (DTCs) have a poor prognosis
mainly owing to radioactive iodine (RAI) refractoriness caused by decreased expression of …

[HTML][HTML] Signal pathway of estrogen and estrogen receptor in the development of thyroid cancer

J Liu, T Xu, L Ma, W Chang - Frontiers in oncology, 2021 - frontiersin.org
… ) signal pathway due to mutations are critical in cancer progression. This review summarizes
the pathways involved in the molecular mechanisms of estrogen and ER in thyroid cancer, …

[HTML][HTML] New therapies for advanced thyroid cancer

D Laha, N Nilubol, M Boufraqech - Frontiers in endocrinology, 2020 - frontiersin.org
pathways in thyroid cancer and to discuss the most recent targeted therapies and
immunotherapy for advanced thyroid cancer with a promising anti-tumor activity and clinical benefit. …

[HTML][HTML] Vitamin C kills thyroid cancer cells through ROS-dependent inhibition of MAPK/ERK and PI3K/AKT pathways via distinct mechanisms

X Su, Z Shen, Q Yang, F Sui, J Pu, J Ma, S Ma… - Theranostics, 2019 - ncbi.nlm.nih.gov
… the antitumor activity of vitamin C in thyroid cancer. … thyroid cancer 14 . We, therefore,
attempted to explore the effect of vitamin C on the activities of these two pathways in thyroid cancer

[HTML][HTML] Baicalein induced apoptosis and autophagy of undifferentiated thyroid cancer cells by the ERK/PI3K/Akt pathway

M Wang, S Qiu, J Qin - American journal of translational research, 2019 - ncbi.nlm.nih.gov
… /Akt pathways. In conclusion, baicalein could suppress the growth of undifferentiated thyroid
cancer … The inhibition of the ERK and PI3K/Akt pathways may be involved in the mechanism. …

Significance of miRNAs on the thyroid cancer progression and resistance to treatment with special attention to the role of cross-talk between signaling pathways

AS Doghish, HA El-Mahdy, A Ismail, M Hegazy… - … -Research and Practice, 2023 - Elsevier
Thyroid cancer (TC) is the most prevalent endocrine malignant tumor. It has many types, the
Papillary thyroid cancer (PTC)(most common and follicular thyroid … signaling pathways such …

[HTML][HTML] Update on fundamental mechanisms of thyroid cancer

A Prete, P Borges de Souza, S Censi… - Frontiers in …, 2020 - frontiersin.org
… The molecular pathogenesis of thyroid cancer involves dysregulation of the mitogen-… (PI3K)/AKT
pathways. Common activating mutations in the MAPK pathway include RET-PTC and …

[HTML][HTML] The role of microRNAs in the pathogenesis of thyroid cancer

S Ghafouri-Fard, Z Shirvani-Farsani, M Taheri - Non-coding RNA research, 2020 - Elsevier
… the activity of thyroid cancer-related signaling pathways such as MAPK pathway and RET …
have differential expression in different stages of thyroid cancer. Assessment of serum levels of …

[HTML][HTML] Molecular alterations in thyroid cancer: from bench to clinical practice

E Tirrò, F Martorana, C Romano, SR Vitale, G Motta… - Genes, 2019 - mdpi.com
… detected in thyroid cancer, we will initially discuss RTK-related upstream signaling pathways
involved in tumorigenesis and subsequently focus on the effectors of these pathways. …

[HTML][HTML] Recent advances in the management of anaplastic thyroid cancer

S De Leo, M Trevisan, L Fugazzola - Thyroid research, 2020 - Springer
… )/AKT/mTOR pathway has been reported in thyroid cancer pathogenesis. Everolimus is a
Sirolimus-derived mTOR inhibitor, whose activity against several thyroid cancer cell lines has …