Outcomes of observation vs stereotactic ablative radiation for oligometastatic prostate cancer: the ORIOLE phase 2 randomized clinical trial

R Phillips, WY Shi, M Deek, N Radwan, SJ Lim… - JAMA …, 2020 - jamanetwork.com
… This study reports the findings of a phase 2 randomized clinical trial of observation vs SABR
in men with hormone-sensitive OMPC, to our knowledge the first in the western hemisphere. …

Durvalumab with or without tremelimumab for patients with metastatic pancreatic ductal adenocarcinoma: a phase 2 randomized clinical trial

EM O'Reilly, DY Oh, N Dhani, DJ Renouf… - JAMA …, 2019 - jamanetwork.com
… To our knowledge, this study is the first phase 2 randomized clinical trial to evaluate dual …
It is important to undertake studies such as this, even though previous research has reported …

[HTML][HTML] … psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials

MC Mithoefer, AA Feduccia, L Jerome, A Mithoefer… - …, 2019 - Springer
… six phase 2 trials in a pooled analysis to determine the study design for phase 3 trials of … is
to present pooled data from randomized clinical trials at different study sites that evaluated the …

… vs pembrolizumab alone on tumor response in patients with advanced non–small cell lung cancer: results of the PEMBRO-RT phase 2 randomized clinical trial

WSME Theelen, HMU Peulen, F Lalezari… - JAMA …, 2019 - jamanetwork.com
… This multicenter, phase 2 randomized clinical trial was conducted at 3 medical sites in the
Netherlands. Patients 18 years or older were eligible to participate if they had histological or …

… dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial

EA Rozeman, AM Menzies, ACJ van Akkooi… - The Lancet …, 2019 - thelancet.com
phase 1 pilot study, patients were randomly assigned to neoadjuvant or adjuvant therapy
with hu14.18-IL-2 … A randomised phase 2 study showed an improved event-free survival with …

Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes: interim analysis of 2 randomized clinical trials

S Xia, K Duan, Y Zhang, D Zhao, H Zhang, Z Xie, X Li… - Jama, 2020 - jamanetwork.com
… Only half of the participants in the phase 2 trial were scheduled for the hormoral … of 2
randomized placebo-controlled trials. In 96 healthy adults in a phase 1 trial of patients randomized

… for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled trial

D Yannopoulos, J Bartos, G Raveendran, E Walser… - The lancet, 2020 - thelancet.com
… We did the first randomised clinical trial in the USA of extracorporeal membrane oxygenation
(ECMO)-facilitated resuscitation versus standard ACLS treatment in patients with OHCA …

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

M Rosenzwajg, R Lorenzon, P Cacoub… - Annals of the …, 2019 - ard.bmj.com
… preliminary indications of clinical efficacy should licence the launch of phase II efficacy trial
of ld-… These results should licence the initiation of randomised controlled trials in numerous …

Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial

JR Sims, JA Zimmer, CD Evans, M Lu, P Ardayfio… - Jama, 2023 - jamanetwork.com
… In the phase 2 TRAILBLAZER-ALZ trial of donanemab vs … -ALZ 2, a global phase 3 randomized
clinical trial that … pathology (the population studied in the phase 2 trial) and in a combined …

Gemcitabine, cisplatin, and nab-paclitaxel for the treatment of advanced biliary tract cancers: a phase 2 clinical trial

RT Shroff, MM Javle, L Xiao, AO Kaseb… - JAMA …, 2019 - jamanetwork.com
… These findings will be tested in a phase 3 randomized clinical trial. … In conclusion, the
present phase 2 clinical trial met its primary end point of a PFS increase among patients with …