A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer?

X Cao, L Ding, Z Xie, Y Yang, M Whiteman… - Antioxidants & redox …, 2019 - liebertpub.com
Hydrogen sulfide (H 2 S) is a colorless gas characterized with a strong rotten egg smell
under … Usually, the intoxication of H 2 S is ascribed to its strong suppressive effect on several …

[HTML][HTML] Hydrogen sulfide in pharmacotherapy, beyond the hydrogen sulfide-donors

E Zaorska, L Tomasova, D Koszelewski, R Ostaszewski… - Biomolecules, 2020 - mdpi.com
… of endogenous hydrogen sulfide. In this work, we review data regarding sulfur drugs …
Notably, a clinical study showed a greater potency of Remikiren to lower blood pressure in …

Modulation of the functions of myeloid‐derived suppressor cells: a new strategy of hydrogen sulfide anti‐cancer effects

P De Cicco, G Ercolano, V Rubino… - British Journal of …, 2020 - Wiley Online Library
… In this study, we assessed the ability of hydrogen sulfide (H 2 S), a gasotransmitter whose
anti‐cancer effects are well known, to inhibit the accumulation and immunosuppressive …

[HTML][HTML] Hydrogen sulfide: An endogenous regulator of the immune system

N Dilek, A Papapetropoulos, T Toliver-Kinsky… - Pharmacological …, 2020 - Elsevier
Hydrogen sulfide (H 2 S) is now recognized as an endogenous signaling gasotransmitter in
mammals. It is produced by mammalian cells and tissues by various enzymes - …

Activatable small-molecule hydrogen sulfide donors

CM Levinn, MM Cerda, MD Pluth - Antioxidants & redox signaling, 2020 - liebertpub.com
Significance: Hydrogen sulfide (H 2 S) is an important biological signaling molecule involved
in many physiological processes. These diverse roles have led researchers to develop …

Hydrogen sulfide donors: Therapeutic potential in anti-atherosclerosis

H Zhang, Z Bai, L Zhu, Y Liang, X Fan, J Li… - European Journal of …, 2020 - Elsevier
Hydrogen sulfide (H 2 S) was discovered as the third gaseous signaling molecule following
nitric oxide (NO) and carbon monoxide (CO), and has been proposed to exert potentially …

Effects of hydrogen sulfide on the microbiome: from toxicity to therapy

AG Buret, T Allain, JP Motta… - Antioxidants & redox …, 2022 - liebertpub.com
… Indeed, microbial adhesion to and invasion through the host epithelium trigger potent … further
support of the importance of H 2 S as a modulator of microbial biofilms (75). However, there …

Anti‐inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H2S donors in COVID‐19 therapy

V Citi, A Martelli, V Brancaleone, S Brogi… - British journal of …, 2020 - Wiley Online Library
… In the last decades, the endogenous gasotransmitter hydrogen sulfide (H 2 S) has emerged
as modulator of several biological functions and its deficiency has been associated with …

[HTML][HTML] Hydrogen sulfide, an endogenous stimulator of mitochondrial function in cancer cells

C Szabo - Cells, 2021 - mdpi.com
Hydrogen sulfide (H 2 S) has a long history as toxic gas and environmental hazard; inhibition
of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its …

SG1002 and catenated divalent organic sulfur compounds as promising hydrogen sulfide prodrugs

G Gojon, GA Morales - Antioxidants & Redox Signaling, 2020 - liebertpub.com
Sulfur has a critical role in protein structure/function and redox status/signaling in all living
organisms. Although hydrogen sulfide (H 2 S) and sulfane sulfur … depth of sulfur metabolome's …