Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

B Wang, L Wu, J Chen, L Dong, C Chen… - … and targeted therapy, 2021 - nature.com
… To explore the role of the AA metabolism and potential therapies, we also introduce the
current newly clinical studies targeting AA metabolisms in the different disease conditions. …

STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review

JJ Qin, L Yan, J Zhang, WD Zhang - … & Clinical Cancer Research, 2019 - Springer
… molecular targets, which underscores the need for developing novel therapeutic and
preventive approaches for this disease. Recent evidence from clinical trials and preclinical studies

Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials

Y Cheng, C He, M Wang, X Ma, F Mo, S Yang… - … and targeted therapy, 2019 - nature.com
… -targeted therapy has been applied in the treatment of hematological malignancies and has
exhibited viable therapeutic potential for solid tumors in preclinical and clinical trials. In this …

Rheumatologists' perspective on coronavirus disease 19 (COVID-19) and potential therapeutic targets

DP Misra, V Agarwal, AY Gasparyan, O Zimba - Clinical rheumatology, 2020 - Springer
… the potential drug therapies in COVID-19 (Table 2). More clinical trials and cohort studies are
… Table 2 Potential drugs for different phases of coronavirus disease 19 (COVID-19), whose …

Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics

Y Wang, S Zhang, F Li, Y Zhou, Y Zhang… - … acids research, 2020 - academic.oup.com
… the clinical trial progression speed of innovative drug targets (50), which states that the
human target entering clinical trials may progress more speedily through the trials if it has no …

The therapeutic potential of curcumin: A review of clinical trials

B Salehi, Z Stojanović-Radić, J Matejić… - European journal of …, 2019 - Elsevier
… Thus, based on this data, the present report aims to provide an extensive overview to clinical
trials assessing the pharmacological effects of curcumin, namely highlighting its therapeutic

Advances in TRP channel drug discovery: from target validation to clinical studies

AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
… Peripheral expression of TRPV1 on nociceptive fibres is predictive of the patient’s
response to capsaicin therapy, which may explain the discrepant outcome in clinical trials with …

The potential for microRNA therapeutics and clinical research

J Hanna, GS Hossain, J Kocerha - Frontiers in genetics, 2019 - frontiersin.org
… A variety of cell culture platforms are now available to assess the mechanisms, toxicity, and
potential therapeutic efficacy of miRNA candidates in vitro. Primary cells, immortalized cell …

The pathogenesis of sepsis and potential therapeutic targets

M Huang, S Cai, J Su - International journal of molecular sciences, 2019 - mdpi.com
… Over the past few decades, numerous medical studies have presented definitions for
sepsis, including those for septicemia, sepsis, toxemia, bacteremia, and endotoxemia [10]. To …

[HTML][HTML] Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

C Wu, Y Liu, Y Yang, P Zhang, W Zhong… - … Pharmaceutica Sinica B, 2020 - Elsevier
study provides drug repositioning candidates and targets for further in vitro and in vivo
studies … for candidate drugs obtained in this study, and prepare for clinical trial applications. …