Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
B Wang, L Wu, J Chen, L Dong, C Chen… - … and targeted therapy, 2021 - nature.com
… To explore the role of the AA metabolism and potential therapies, we also introduce the
current newly clinical studies targeting AA metabolisms in the different disease conditions. …
current newly clinical studies targeting AA metabolisms in the different disease conditions. …
STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review
… molecular targets, which underscores the need for developing novel therapeutic and
preventive approaches for this disease. Recent evidence from clinical trials and preclinical studies …
preventive approaches for this disease. Recent evidence from clinical trials and preclinical studies …
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Y Cheng, C He, M Wang, X Ma, F Mo, S Yang… - … and targeted therapy, 2019 - nature.com
… -targeted therapy has been applied in the treatment of hematological malignancies and has
exhibited viable therapeutic potential for solid tumors in preclinical and clinical trials. In this …
exhibited viable therapeutic potential for solid tumors in preclinical and clinical trials. In this …
Rheumatologists' perspective on coronavirus disease 19 (COVID-19) and potential therapeutic targets
… the potential drug therapies in COVID-19 (Table 2). More clinical trials and cohort studies are
… Table 2 Potential drugs for different phases of coronavirus disease 19 (COVID-19), whose …
… Table 2 Potential drugs for different phases of coronavirus disease 19 (COVID-19), whose …
Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics
… the clinical trial progression speed of innovative drug targets (50), which states that the
human target entering clinical trials may progress more speedily through the trials if it has no …
human target entering clinical trials may progress more speedily through the trials if it has no …
The therapeutic potential of curcumin: A review of clinical trials
B Salehi, Z Stojanović-Radić, J Matejić… - European journal of …, 2019 - Elsevier
… Thus, based on this data, the present report aims to provide an extensive overview to clinical
trials assessing the pharmacological effects of curcumin, namely highlighting its therapeutic …
trials assessing the pharmacological effects of curcumin, namely highlighting its therapeutic …
Advances in TRP channel drug discovery: from target validation to clinical studies
AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
… Peripheral expression of TRPV1 on nociceptive fibres is predictive of the patient’s
response to capsaicin therapy, which may explain the discrepant outcome in clinical trials with …
response to capsaicin therapy, which may explain the discrepant outcome in clinical trials with …
The potential for microRNA therapeutics and clinical research
J Hanna, GS Hossain, J Kocerha - Frontiers in genetics, 2019 - frontiersin.org
… A variety of cell culture platforms are now available to assess the mechanisms, toxicity, and
potential therapeutic efficacy of miRNA candidates in vitro. Primary cells, immortalized cell …
potential therapeutic efficacy of miRNA candidates in vitro. Primary cells, immortalized cell …
The pathogenesis of sepsis and potential therapeutic targets
M Huang, S Cai, J Su - International journal of molecular sciences, 2019 - mdpi.com
… Over the past few decades, numerous medical studies have presented definitions for
sepsis, including those for septicemia, sepsis, toxemia, bacteremia, and endotoxemia [10]. To …
sepsis, including those for septicemia, sepsis, toxemia, bacteremia, and endotoxemia [10]. To …
[HTML][HTML] Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods
C Wu, Y Liu, Y Yang, P Zhang, W Zhong… - … Pharmaceutica Sinica B, 2020 - Elsevier
… study provides drug repositioning candidates and targets for further in vitro and in vivo
studies … for candidate drugs obtained in this study, and prepare for clinical trial applications. …
studies … for candidate drugs obtained in this study, and prepare for clinical trial applications. …
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