… ” interventions for specific abnormalities of the cystic fibrosis … with CF worldwide—barriers
to precision therapy remain. These … has occurred regarding CF precision medicine, this review …

… Cystic fibrosis (CF) is a severe, monogenic, autosomal recessive disease caused by
mutations in the CFTR (cystic fibrosis transmembrane regulator) gene, where disturbed chloride …

… Cystic fibrosis (CF) is a lethal inherited disease caused by mutations in the CF … Mutations
in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (…

… It was originally anticipated that well-established disease subclasses would serve as an
organizing principle for precision CF treatments and help identify specific compounds for …

… The genetic multisystem condition cystic fibrosis (CF) has seen a paradigm shift in … , treatment
advances had focused on the downstream consequences of a dysfunctional cystic fibrosis …

… of precision treatment for cystic fibrosis using small-molecule therapeutics has created a
need to estimate potential clinical improvements attributable to increases in cystic fibrosis …

… cystic fibrosis transmembrane conductance regulator gene. This causes multisystem disease
due to dysfunction of the cystic fibrosis … Until recently, treatment was directed at managing …

… Our understanding of cystic fibrosis (CF) has grown exponentially since the discovery of
the cystic fibrosis transmembrane conductance regulator (CFTR) gene in 1989. With evolving …

… with cystic fibrosis who are genetically eligible for treatment, … the pathogenesis of cystic
fibrosis, working together with a … of the lungs of people with cystic fibrosis. We review progress in (…

… propose adequate treatments. Conversely, cis-variants can affect treatment response when
… We wish to thank the French cystic fibrosis association Vaincre la mucoviscidose for funding …