… the unfolded protein response (UPR), a signal transduction pathway that senses the fidelity
of protein folding in the ER lumen. The UPR transmits information about protein folding status …

… or misfolded proteins in the endoplasmic reticulum (ER). ER proteostasis is governed by
the unfolded protein response (UPR), a signalling pathway that adjusts the protein-folding …

… protein response (… response to fluctuating levels of unfolded proteins. BiP activity is tied to
the regulation of the UPR transducers by a recently discovered cycle of ER-localized, J protein–…

… of unfolded proteins, a … protein response (UPR) pathway in order to restore protein
homeostasis. Three ER membrane proteins, namely inositol-requiring enzyme 1 (IRE1), protein …

… Transformed cells must meet increased demands for protein … protein response (UPR). The
UPR is a pro-survival mechanism triggered by accumulation of unfolded or misfolded proteins …

… , the protein-folding status in the organelle's lumen is continually surveyed by a network
of signaling pathways, collectively called the unfolded protein response (UPR). Protein-folding …

… defects causes accumulation of mitochondrial precursor proteins in the cytosol and cell …
protein response activated by mistargeted proteins) is activated during mitochondrial protein …

… protein response (UPR) plays a central role in regulating endoplasmic reticulum (ER) and
global cellular physiology in response … proteins IRE1, ATF6, and PERK. Once activated, these …

… in perturbations in protein folding and trafficking [4, 47,48,49,50,51,52,53]. Erratic protein
folding activates another specific stress response pathway, the unfolded protein response (UPR…

… of the Unfolded Protein Response (UPR), a cellular adaptive reaction to accommodate
protein-folding stress. Accumulation of unfolded or misfolded proteins in the Endoplasmic …