Multiepitope supramolecular peptide nanofibers eliciting coordinated humoral and cellular antitumor immune responses
Y Wu, H Wen, ZJ Bernstein, KM Hainline… - Science …, 2022 - science.org
… responses (30, 35), so to generate T H 1-biased humoral responses for antitumor efficacy,
we additionally used CpG, a Toll-like receptor 9 (TLR9) agonist (46–48), as an adjuvant in all …
we additionally used CpG, a Toll-like receptor 9 (TLR9) agonist (46–48), as an adjuvant in all …
[HTML][HTML] A Self-Assembling Lipidic Peptide and Selective Partial V2 Receptor Agonist Inhibits Urine Production
S Patel, AB Volpe, S Awwad, AG Schätzlein… - Scientific Reports, 2020 - nature.com
… We sought to examine if a lipidized peptide, which assembles into nanofibers could serve
as a selective V2 receptor agonist and control urine production. Such a compound may serve …
as a selective V2 receptor agonist and control urine production. Such a compound may serve …
Self‐Assembled Peptide Amphiphile Nanofibers for Controlled Therapeutic Delivery to the Atherosclerotic Niche
EB Peters, MR Karver, K Sun, DC Gillis… - Advanced …, 2021 - Wiley Online Library
… As a model therapeutic, we chose liver X receptor agonist GW3965 (LXR), which restores
lipid homeostasis by stimulating cholesterol efflux from macrophage foam cells through …
lipid homeostasis by stimulating cholesterol efflux from macrophage foam cells through …
Incorporation of the tat cell‐penetrating peptide into nanofibers improves the respective antitumor immune response
M Mohammadi, P Dehghani… - Journal of cellular …, 2021 - Wiley Online Library
… Modern subunit vaccine (epitope-based vaccine) require powerful immuno stimulant
adjuvants such as toll like receptor agonists (ie, synthetic CpG-oligonucleotides) whereby can …
adjuvants such as toll like receptor agonists (ie, synthetic CpG-oligonucleotides) whereby can …
[HTML][HTML] Dual-ligand supramolecular nanofibers inspired by the renin-angiotensin system for the targeting and synergistic therapy of myocardial infarction
Z Wen, J Zhan, H Li, G Xu, S Ma, J Zhang, Z Li, C Ou… - Theranostics, 2021 - ncbi.nlm.nih.gov
… nanofibers, we designed and synthesized a peptide … of its degradation 42 ; the vasoactive
peptide Ang1-7 (DRVYIHP) … ACEI, ARBs, and AT2 receptor agonists. However, the limited …
peptide Ang1-7 (DRVYIHP) … ACEI, ARBs, and AT2 receptor agonists. However, the limited …
[HTML][HTML] From antigen uptake to immune modulation: the multifaceted potential of peptide nanofibers as vaccine nanocarriers
… Evaluation of the peptide nanofibers' capabilities has … These results suggest that peptide
nanofibers could amplify the … This review highlights the potential utility of peptide nanofibers as …
nanofibers could amplify the … This review highlights the potential utility of peptide nanofibers as …
[HTML][HTML] A Targeted Nanofiber Loaded With Liver X Receptor Agonist Reduces Atherosclerotic Plaque and Prevents Hepatotoxicity
… ApoA1-targeted peptide amphiphile nanofibers to … nanofibers as quantified by mass
spectrometry, and a critical aggregation concentration of <0.1 μM for the ApoA1-GW3965 nanofibers. …
spectrometry, and a critical aggregation concentration of <0.1 μM for the ApoA1-GW3965 nanofibers. …
Comparative study of α-helical and β-sheet self-assembled peptide nanofiber vaccine platforms: influence of integrated T-cell epitopes
Several different self-assembling peptide systems that form nanofibers have been … dissimilar
peptide nanofibers, one a β-sheet fibrillar system (Q11), and one an α-helical nanofiber …
peptide nanofibers, one a β-sheet fibrillar system (Q11), and one an α-helical nanofiber …
Combining Biologically Active β-Lactams Integrin Agonists with Poly(l-lactic acid) Nanofibers: Enhancement of Human Mesenchymal Stem Cell Adhesion
G Martelli, N Bloise, A Merlettini, G Bruni… - …, 2020 - ACS Publications
Regulating stem cell adhesion and growth onto functionalized biomaterial scaffolds is an
important issue in the field of tissue engineering and regenerative medicine. In this study, new …
important issue in the field of tissue engineering and regenerative medicine. In this study, new …
Supramolecular nanofibers with superior bioactivity to insulin-like growth factor-I
Y Shang, D Zhi, G Feng, Z Wang, D Mao, S Guo… - Nano Letters, 2019 - ACS Publications
… supramolecular nanofibers containing the QK peptide that mimics VEGF. The QK peptide is
… of supramolecular nanofibers significantly increases the half-life of QK peptides in an egg …
… of supramolecular nanofibers significantly increases the half-life of QK peptides in an egg …
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