… The heme oxygenases (HO) other than provide for heme degradation also participate in
cellular defense. It was observed that the activation of HO-1 is a ubiquitous cellular response to …

This Forum issue “Heme Oxygenase” (HO) includes original research articles and reviews
that are aimed at understanding the role of HO-1 in several pathophysiological conditions, …

… product of heme metabolism by two sequential reactions catalyzed by heme oxygenase and
… Mice with deletion of heme oxygenase-2 or biliverdin reductase display greater lipid than …

… The heme oxygenase (HO) system is essential for heme and … HO degrades heme to biliverdin
(BV), carbon monoxide (CO) and … , heme also contributes to the regulation of the redox …

… heme oxygenase, designated heme oxygenase-1 (HO1) and heme oxygenase-2 (HO2). HO1
and HO2 degrade … The C-terminal heme regulatory motifs of heme oxygenase-2 are redox-…

… redox state of iron in heme complexes can vary. Among redox states, the two most common
are the heme … of genes encoding heme oxygenase and the ABC-type heme exporter, …

… of the heme redox state, CO, and heme binding affinities. … Our own studies have focused
on heme oxygenase-2 (HO2) … /disulfide redox switch, an additional level of redox regulation …

… a | Immunomodulatory activity of haem oxygenase … regulatory factor 3 (IRF3) activation in
response to pro-inflammatory stimuli and permits macrophages to regulate local iron and redox …

… Heme oxygenase catalyzes the rate-limiting step in heme degradation in order to generate
… , heme oxygenase-1 (HO-1), exerts a central role in cellular protection. The substrate, heme, …

… contain Cys-Pro motifs whose binding affinity for heme is subject to redox regulation. Ferric
… HO-1 may regulate heme bioavailability in these compartments as well as provide a localized …