Uric acid levels are higher in humans than in other mammals. Best known as an
extracellular antioxidant, uric acid also increases salt sensitivity, fat storage, and …

Uric acid is the final product of purine metabolism, and its increased serum levels have been
directly involved in the pathogenesis and natural history of hypertension. The relationship …

The association between serum uric acid levels and high blood pressure in humans is well
established. For example, a cross-sectional study determined that each 1mg/dL increase in …

A direct relationship between serum uric acid levels and hypertension, cardiovascular, renal
and metabolic diseases has been reported in many basic and epidemiological studies …

Uric acid is associated with cardiovascular disease and cardiovascular disease risk factors
in adults, including chronic kidney disease, coronary artery disease, stroke, diabetes …

The association between increased serum urate and hypertension has been a subject of
intense controversy. Extracellular uric acid drives uric acid deposition in gout, kidney stones …

Serum uric acid was first noted to be associated with increased BP by Frederick Mohamed in
the 1870s. Although the link was rediscovered periodically over the years, it generally was …

Hyperuricemia is associated with hypertension, vascular disease, renal disease, and
cardiovascular events. In this report, we review the epidemiologic evidence and potential …

J Clin Hypertens (Greenwich). 2012; 14: 346–352.© 2012 Wiley Periodicals, Inc. Uric acid
has been suspected to be a risk factor for hypertension since the 1870s. Numerous …

Epidemiologic studies published during the past 3 years support the possible role of uric
acid in the onset of essential hypertension. Data from several large, longitudinal …