[HTML][HTML] Endophenotypes in schizophrenia: digging deeper to identify genetic mechanisms
TA Greenwood, A Shutes-David… - Journal of psychiatry …, 2019 - ncbi.nlm.nih.gov
Schizophrenia (SZ) is a severe psychotic disorder that is highly heritable and common in the
general population. The genetic heterogeneity of SZ is substantial, with contributions from …
general population. The genetic heterogeneity of SZ is substantial, with contributions from …
The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: a collaborative cognitive and neuroimaging genetics project
Background Schizophrenia has a large genetic component, and the pathways from genes to
illness manifestation are beginning to be identified. The Genetics of Endophenotypes of …
illness manifestation are beginning to be identified. The Genetics of Endophenotypes of …
Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci
BackgroundEndophenotypes are laboratory-based measures hypothesized to lie in the
causal chain between genes and clinical disorder, and to serve as a more powerful way to …
causal chain between genes and clinical disorder, and to serve as a more powerful way to …
Schizophrenia genomics: genetic complexity and functional insights
Determining the causes of schizophrenia has been a notoriously intractable problem,
resistant to a multitude of investigative approaches over centuries. In recent decades …
resistant to a multitude of investigative approaches over centuries. In recent decades …
Genome-wide association of endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia (COGS) study
Importance The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative
neurophysiological and neurocognitive endophenotypes with demonstrated deficits in …
neurophysiological and neurocognitive endophenotypes with demonstrated deficits in …
[HTML][HTML] Lessons learned from parsing genetic risk for schizophrenia into biological pathways
The clinically heterogeneous presentation of schizophrenia is compounded by the
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …
Genetic insight of schizophrenia: past and future perspectives
A Kumar, S Agarwal, SR Phadke, Y Jaiswal - Gene, 2014 - Elsevier
Schizophrenia (SCZ) has a heritability of about 80%, and the search for the genetic basis of
this disease has been frustrating. Because schizophrenia has no distinguishing pathology or …
this disease has been frustrating. Because schizophrenia has no distinguishing pathology or …
Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder
DL Braff, R Freedman, NJ Schork… - Schizophrenia …, 2007 - academic.oup.com
The genetics of schizophrenia has been approached utilizing a variety of methods. One
emerging strategy is the use of endophenotypes in order to understand and identify the …
emerging strategy is the use of endophenotypes in order to understand and identify the …
Genes and environments in schizophrenia: the different pieces of a manifold puzzle
JM Réthelyi, J Benkovits, I Bitter - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
Genetic research targeting schizophrenia has undergone tremendous development during
recent years. Supported by recently developed high-throughput genotyping technologies …
recent years. Supported by recently developed high-throughput genotyping technologies …
The importance of endophenotypes in schizophrenia research
DL Braff - Schizophrenia research, 2015 - Elsevier
Endophenotypes provide a powerful neurobiological platform from which we can
understand the genomic and neural substrates of schizophrenia and other common complex …
understand the genomic and neural substrates of schizophrenia and other common complex …