Decreased renal blood flow following an ischemic insult contributes to a reduction in
glomerular filtration. However, little is known about the underlying cellular or subcellular …

Background Vascular congestion of the renal medulla—trapped red blood cells in the
medullary microvasculature—is a hallmark finding at autopsy in patients with ischemic acute …

Acute kidney injury is associated with alterations in vascular tone that contribute to an
overall reduction in GFR. Studies in animal models indicate that ischemia triggers alterations …

Increased pressure due to postischemic edema aggravates renal ischemia-reperfusion
injury (IRI). Prophylactic surgical decompression using microcapsulotomy improves kidney …

Acute kidney injury (AKI) is a serious multifactorial conditions accompanied by the loss of
function and damage. The renal microcirculation plays a crucial role in maintaining the …

The kidney is comprised of heterogeneous cell populations that function together to perform
a number of tightly controlled, complex and interdependent processes. Renal endothelial …

Endothelial cells play a key role in initiating and propagating the inflammatory response
seen in ischemia, infections and sepsis. Situated in a key position between the epithelial …

Acute renal failure (ARF) severely worsens prognosis of hospitalized patients. The most
frequent cause of intrarenal ARF is transient or prolonged renal hypoperfusion (ischemia) …

Background. Neutrophils play a major role in ischemia/reperfusion injury (IRI) in renal
transplantation and acute kidney injury. However, it has been difficult to observe changes in …

Introduction: Ischemia-reperfusion injury (IRI) results in cellular damage, production of free
oxygen radicals, and subsequent apoptosis. During partial nephrectomy, the renal hilum is …