Background: Myocardial hypertrophy, when pathological and sustained, is one of the
predictors of cardiovascular morbidity. Telmisartan (TEL) and trimetazidine (TMZ) are drugs …

The aim of the present study was to examine the role of sirtuin 3 (Sirt3)‑autophagy in
regulating myocardial energy metabolism and inhibiting myocardial hypertrophy in …

Autophagy is activated in hypertension-induced cardiac hypertrophy. However, the
mechanisms and significance of an activated autophagy are not clear. This study was …

This study aimed to investigate whether matrine (Ma) attenuates isoproterenol (ISO)-induced
acute myocardial hypertrophy via activating Akt/mTOR/p70S6K/eIF4E signaling pathway in …

Objective To observe changes of left ventricular function and the level of autophagy after
treatment with trimetazine in rats with heart failure after myocardial infarction (MI). Methods …

OBJECTIVE: Curcumin has been reported to possess cardioprotective effects. However, the
potential molecular mechanism of curcumin is still not clear. The aim of the present study …

Objective To investigate the effect and mechanism of astragaloside Ⅳ (AS-Ⅳ) activating
ROCK/JNK to regulate autophagy in improving isoproterenol (ISO) induced myocardial …

Mechanical stress can induce cardiac hypertrophy and autophagy. Recently, it has been
reported that nitric oxide donors inhibited autophagy in human chondrocytes. Therefore, the …

Autophagy serves a role in preserving cellular homeostasis. Diabetes mellitus (DM) impairs
cardiac autophagy and is associated with an accumulation of cytotoxic proteins that may …

Congestive heart failure (CHF) is mainly resulted from fibrosis heart. Accumulation collagen
in heart fibrosis occurs as result from activity of myofibroblast [1-4]. Myofibroblast is throught …