[HTML][HTML] Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment
RA Clewell, CM Thompson, HJ Clewell III - Chemico-Biological Interactions, 2019 - Elsevier
Current regulatory practices for chemical carcinogens were established when scientific
understanding of the molecular mechanisms of chemical carcinogenesis was in its infancy …
understanding of the molecular mechanisms of chemical carcinogenesis was in its infancy …
Susceptibility differences in chemical carcinogenesis linearize the dose–response relationship: threshold doses can be defined only for individuals
WK Lutz - … Research/Fundamental and Molecular Mechanisms of …, 2001 - Elsevier
The debate on thresholds in dose–response relationships for chemical carcinogenesis
concentrates on the question of mechanisms of action that come into play only at dose levels …
concentrates on the question of mechanisms of action that come into play only at dose levels …
Dose–response relationships in chemical carcinogenesis: superposition of different mechanisms of action, resulting in linear–nonlinear curves, practical thresholds, J …
WK Lutz - … Research/Fundamental and Molecular Mechanisms of …, 1998 - Elsevier
The shape of a carcinogen dose–cancer incidence curve is discussed as the result of a
superposition of dose–response relationships for various effects of the carcinogen on the …
superposition of dose–response relationships for various effects of the carcinogen on the …
DNA reactivity as a mode of action and its relevance to cancer risk assessment
RJ Preston - Toxicologic pathology, 2013 - journals.sagepub.com
The ability of a chemical to induce mutations has long been a driver in the cancer risk
assessment process. The default strategy has been that mutagenic chemicals demonstrate …
assessment process. The default strategy has been that mutagenic chemicals demonstrate …
Possible mechanisms underlying genotoxic thresholds: DNA repair and translesion DNA synthesis
T Nohmi, T Tsuzuki - Thresholds of Genotoxic carcinogens, 2016 - Elsevier
Currently, chemical carcinogens are classified into two groups, that is, genotoxic
carcinogens and nongenotoxic carcinogens. The former are chemicals that induce tumors …
carcinogens and nongenotoxic carcinogens. The former are chemicals that induce tumors …
Nongenotoxic carcinogens in the regulatory environment
BE Butterworth - Regulatory Toxicology and Pharmacology, 1989 - Elsevier
The biological activity of many carcinogens is to directly induce mutational events, thereby
altering the information encoded in the DNA. Short-term tests for potential carcinogens and …
altering the information encoded in the DNA. Short-term tests for potential carcinogens and …
Biomarkers in toxicology and risk assessment: informing critical dose–response relationships
JA Swenberg, E Fryar-Tita, YC Jeong… - Chemical research in …, 2008 - ACS Publications
Tremendous advances have been made in the study of biomarkers related to
carcinogenesis during the past 20 years. This perspective will briefly review improvements …
carcinogenesis during the past 20 years. This perspective will briefly review improvements …
[图书][B] The cellular response to the genotoxic insult: The question of threshold for genotoxic carcinogens
H Greim, RJ Albertini - 2012 - books.google.com
Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer.
Typically, a series of mutation events are needed before malignancy occurs so a single …
Typically, a series of mutation events are needed before malignancy occurs so a single …
[图书][B] Thresholds of genotoxic carcinogens: from mechanisms to regulation
T Nohmi, S Fukushima - 2016 - books.google.com
Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together
current opinion and research activities from Japan, the US, and Europe on the subject of …
current opinion and research activities from Japan, the US, and Europe on the subject of …
US Environmental Protection Agency's revised guidelines for carcinogen risk assessment: evaluating a postulated mode of carcinogenic action in guiding dose …
JA Wiltse, VL Dellarco - Mutation Research/Genetic Toxicology and …, 2000 - Elsevier
There are new opportunities to using data from molecular and cellular studies in order to
bring together a fuller biological understanding of how chemicals induce neoplasia. In 1996 …
bring together a fuller biological understanding of how chemicals induce neoplasia. In 1996 …