The health risk manager and policy analyst must frequently make recommendations based
upon incomplete toxicity data. This is a situation which is encountered in the evaluation of …

It is generally accepted that exposure to noxious chemicals is the single most important
contributor to the incidence of human cancer. Invariably, exposure to such chemicals is …

It has been known for decades that mutagenicity plays an important role in the activity of
most carcinogens. This mutagenicity can result from direct damage to DNA through a …

This volume will provide a contemporary account of advances in chemical carcinogenesis. It
will promote the view that it is chemical alteration of the DNA that is a route cause of many …

Mutational mechanisms can be proposed as contributing to the activity of most human
carcinogens. Many of these chemicals are electrophilic or are metabolically activated to …

Chemical carcinogenesis is considered to be a multistage process involving genetic and
epigenetic lesions that activate protooncogenes and inactivate tumor suppressor genes …

Should federal agencies use separate, less stringent guidelines for regulating epigenetic or
nongenotoxic carcinogens on the assumption that thresholds are likely to exist for these …

Regulators have adopted the assumption of low dose linearity in cancer risk assessment,
variously justified as scientifically correct and as responsible public health policy. Corollary …

Chemical risk assessment is a complex process that requires integration of various
biological data from test species, ultimately producing a prediction of the expected outcome …

Chemical carcinogenesis is a multistep process. Genotoxic carcinogens, which are DNA-
reactive, induce DNA adduct formation and genetic alterations in target cells, thereby …