Trimethylamine (TMA) is an important gut microbial metabolite strongly associated with
human disease. There are prominent gaps in our understanding of how TMA is produced …

The production of trimethylamine (TMA) from quaternary amines such as l-carnitine or γ-
butyrobetaine (4-(trimethylammonio) butanoate) by gut microbial enzymes has been linked …

L-carnitine, a nutrient in red meat, was recently reported to accelerate atherosclerosis via a
metaorganismal pathway involving gut microbial trimethylamine (TMA) formation and host …

The trimethylamine methyltransferase MttB is the first described member of a superfamily
comprising thousands of microbial proteins. Most members of the MttB superfamily are …

The bacterial formation of trimethylamine (TMA) has been linked to cardiovascular disease.
This review focuses on the methods employed to investigate the identity of the bacteria …

BACKGROUND. l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis
in mice via gut microbiota–dependent formation of trimethylamine (TMA) and trimethylamine …

Background Trimethylamine (TMA), produced by the gut microbiota from dietary quaternary
amines (mainly choline and carnitine), is associated with atherosclerosis and severe …

Purpose Plasma trimethylamine-N-oxide (TMAO) levels have been shown to correlate with
increased risk of metabolic diseases including cardiovascular diseases. TMAO exposure …

Human gut bacteria metabolize dietary components such as choline and carnitine to
trimethylamine (TMA) that is subsequently oxidized to trimethylamine-N-oxide (TMAO) by …

Background The dietary methylamines choline, carnitine, and phosphatidylcholine are used
by the gut microbiota to produce a range of metabolites, including trimethylamine (TMA) …