Decades ago when I was in medical school, our medical professors always said that the
prognosis of heart failure was worse than cancer. Perhaps this was true before I stumbled …

Congestive heart failure (CHF) and dilated cardiomyopathy are life-threatening conditions in
which the heart muscle is so weak that effective pulsatile action is compromised. Pulmonary …

This chapter shows that the bottom line in the treatment of any form of cardiovascular
disease, and especially in congestive heart failure (CHF), is the restoration of the heart's …

The importance of supporting energy production in heart cells and the preservation of the
mitochondria in these cells will be the focus of a new frontier in cardiovascular prevention …

Although neurohumoral antagonism has successfully reduced heart failure morbidity and
mortality, the residual disability and death rate remains unacceptably high. Though …

The consensus opinion is that failing hearts are energy starved. Disruption in the metabolic
processes controlling myocardial energy metabolism is characteristic in failing hearts, and …

The concept of metabolic modulation in the treatment heart failure has been extensively
reviewed in several recent publications (1–3). Over the past decades, several dugs that …

Despite current therapies, which provide substantial benefits to patients, heart failure
remains a progressive disease, and new approaches to treatment are necessary …

Despite standard therapies, heart failure patients have high rates of morbidity highlighting
the need to develop alternative therapeutic approaches. Heart failure has been described as …

There are a myriad of structural and biochemical abnormalities associated with the failing
heart, yet the hallmark of this syndrome is the inability to effectively transfer the chemical …