Mitochondrial permeability transition pore (mPTP) is a channel that opens at the inner
mitochondrial membrane under conditions of stress. Sirtuin 3 (Sirt3) is a mitochondrial …

The sustained opening of the mitochondrial permeability transition pore (PTP) is a decisive
event in the onset of irreversible cell injury. The PTP is modulated by numerous exogenous …

SIRT3, SIRT4, and SIRT5 are mitochondrial deacylases that impact multiple facets of energy
metabolism and mitochondrial function. SIRT3 activates several mitochondrial enzymes …

Mitochondrial permeability transition pore (mPTP) opening is critical to mitochondrial
apoptosis during ischemic injury. Sirtuin 3 (Sirt3) is a mitochondrial deacetylase known to …

Mitochondrial damage is involved in many pathophysiological processes, such as tumor
development, metabolism, and neurodegenerative diseases. The mitochondrial unfolded …

The energy production and metabolic homeostasis are well-orchestrated networks of
carbohydrate, lipid and protein metabolism. These metabolic pathways are integrated by a …

The incidence of type 2 diabetes mellitus (T2DM) and diabetic kidney disease (DKD) has
significantly increased worldwide in recent decades, and improved treatments for T2DM and …

Ischemia is a major cause of kidney damage. Proximal tubular epithelial cells (PTECs) are
highly susceptible to ischemic insults that frequently cause acute kidney injury (AKI), a …

The maintenance of metabolic homeostasis requires the well-orchestrated network of
several pathways of glucose, lipid and amino acid metabolism. Mitochondria integrate these …

Mitochondria are the metabolic hubs that process a number of reactions including
tricarboxylic acid cycle, β-oxidation of fatty acids and part of the urea cycle and pyrimidine …