Fabricating nanoparticles co-loaded with survivin siRNA and Pt (IV) prodrug for the treatment of platinum-resistant lung cancer
S Ma, X Li, M Ran, M Ji, J Gou, T Yin, H He… - International journal of …, 2021 - Elsevier
Resistance to platinum agents is a crucial challenge in the treatment of cancer using
platinum drugs. To overcome the resistance of cells, the survivin protein is supposed to be …
platinum drugs. To overcome the resistance of cells, the survivin protein is supposed to be …
Co-delivery of paclitaxel and survivin shRNA by pluronic P85-PEI/TPGS complex nanoparticles to overcome drug resistance in lung cancer
J Shen, Q Yin, L Chen, Z Zhang, Y Li - Biomaterials, 2012 - Elsevier
Drug resistance is a main obstacle for the successful chemotherapy of lung cancer. In this
work, a new co-delivery system, P85-PEI/TPGS/PTX/shSur complex nanoparticles (PTPNs) …
work, a new co-delivery system, P85-PEI/TPGS/PTX/shSur complex nanoparticles (PTPNs) …
[HTML][HTML] Role of survivin in bladder cancer: Issues to be overcome when designing an efficient dual nano-therapy
M Arista-Romero, A Cascante, C Fornaguera, S Borrós - Pharmaceutics, 2021 - mdpi.com
Bladder cancer is the 10th most diagnosed cancer, with almost 10 M cancer deaths last year
worldwide. Currently, chemotherapy is widely used as adjuvant therapy after surgical …
worldwide. Currently, chemotherapy is widely used as adjuvant therapy after surgical …
Co-delivery of paclitaxel and survivin siRNA with cationic liposome for lung cancer therapy
C Zhang, S Zhang, D Zhi, Y Zhao, S Cui… - Colloids and Surfaces A …, 2020 - Elsevier
This work designed a new delivery system (L-PTX-PSur), which could efficiently co-deliver
paclitaxel (PTX) and survivin siRNA (Sur) to overcome the dose-limiting toxicity by effectively …
paclitaxel (PTX) and survivin siRNA (Sur) to overcome the dose-limiting toxicity by effectively …
The suppression of metastatic lung cancer by pulmonary administration of polymer nanoparticles for co-delivery of doxorubicin and Survivin siRNA
C Xu, H Tian, P Wang, Y Wang, X Chen - Biomaterials science, 2016 - pubs.rsc.org
A pH-sensitive co-delivery system was designed for the treatment of metastatic lung cancers
by pulmonary delivery of doxorubicin (DOX) and Survivin siRNA. Conjugates PEI-BMPH …
by pulmonary delivery of doxorubicin (DOX) and Survivin siRNA. Conjugates PEI-BMPH …
Polymeric micelles containing reversibly phospholipid-modified anti-survivin siRNA: a promising strategy to overcome drug resistance in cancer
The discovery that survivin, a small anti-apoptotic protein, is involved in chemoresistance,
opens a new scenario to overcome the drug resistance in cancer. It was shown that siRNA …
opens a new scenario to overcome the drug resistance in cancer. It was shown that siRNA …
Silencing of survivin and cyclin B1 through siRNA-loaded arginine modified calcium phosphate nanoparticles for non-small-cell lung cancer therapy
With the development of nanotechnology, various drug delivery systems including inorganic
nanoparticles, liposomes, polymers, etc. have been developed over the past decade. Some …
nanoparticles, liposomes, polymers, etc. have been developed over the past decade. Some …
Smart polymeric nanoparticles with pH-responsive and PEG-detachable properties for co-delivering paclitaxel and survivin siRNA to enhance antitumor outcomes
M Jin, G Jin, L Kang, L Chen, Z Gao… - International journal of …, 2018 - Taylor & Francis
Background The co-delivery of chemotherapeutic agents and small interfering RNA (siRNA)
within one cargo can enhance the anticancer outcomes through its synergistic therapeutic …
within one cargo can enhance the anticancer outcomes through its synergistic therapeutic …
Anti-tumor effects in mice induced by survivin-targeted siRNA delivered through polysaccharide nanoparticles
Recently, survivin has been attracting great attention because it plays an important role in
inhibiting the apoptosis process of tumor cells. Down-regulating the expression of survivin …
inhibiting the apoptosis process of tumor cells. Down-regulating the expression of survivin …
Enhancement of cisplatin sensitivity in lung cancer xenografts by liposome-mediated delivery of the plasmid expressing small hairpin RNA targeting Survivin
H Tian, S Liu, J Zhang, S Zhang… - Journal of …, 2012 - ingentaconnect.com
Survivin, a member of the inhibitor of apoptosis protein (IAP) family, is abundantly expressed
in a variety of cancer cells, including lung cancer cells, resulting in low sensitivity of these …
in a variety of cancer cells, including lung cancer cells, resulting in low sensitivity of these …