According to Globocan 2020, breast cancer is considered one of the most common cancers
affecting women and is one of the leading causes of death in over 100 countries. The …

Polypeptide carriers have a good cell compatibility, rich functionality, and facile synthesis
and modification, make them promising materials as siRNA vectors. Phenylalanine …

Here, polyethylenimine (PEI) modified silk fibroin nanoparticles (SFNPs) were prepared for
codelivery of doxorubicin (DOX) and survivin siRNA. The prepared NPs were characterized …

Non-hepatic delivery of small interfering RNA (siRNA) remains a challenge for the
development of RNA interference (RNAi)-based therapeutics. Inhalation is a straightforward …

Purpose Lung cancer remains the leading cancer-associated deaths worldwide. Cisplatin
(CIS) was often used in combination with other drugs for the treatment of non-small cell lung …

Endogenous survivin expression has been related with cancer survival, drug resistance, and
metastasis. Therapies targeting survivin have been shown to significantly inhibit tumor …

Osteosarcoma is the most common malignant bone tumor in children and adolescents.
Treatment usually requires surgical removal of all detectable cancerous tissue and multidrug …

Prolonged circulation, specific and effective uptake by tumor cells, and rapid intracellular
drug release are three main factors for the drug delivery systems to win the battle against …

Although novel molecular targeted drugs have been recognized as an effective therapy for
non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) …

Small interfering RNA (siRNA) for silencing genes and treating disease has been a dream
since ranking as a top Breakthrough of the Year in 2002 by Science. With the recent FDA …