The pRNA (packaging RNA) of bacteriophage phi29 DNA packaging motor has been
reported to have novel applications in nanotechnology and nanomedicine. The unique …

Selectively targeted drug delivery systems are preferable chemotherapeutic platforms, as
they specifically deliver the drug cargo into tumor cells, while minimizing untoward toxic …

Post-transcriptional silencing of antiapoptotic genes is a promising strategy for cancer
therapy, but delivering short interfering RNA (siRNA) molecules against such targets is …

Background: The present study focuses on biodistribution profile and pharmacokinetic
parameters of EGFR-targeted chitosan nanoparticles (TG CS nanoparticles) for …

Survivin is known to be highly-expressed in various carcinomas; and is associated with their
biologically aggressive characteristics and drug resistance. We have previously reported …

Survivin is a new member of the inhibitors of apoptosis family and upregulated in various
human malignancies including human lung cancer. In this study, we proposed a new …

This study developed a pH-sensitive anionic system composed of guanidinylated O-
carboxymethyl chitosan (GOCMCS) and N-2-hydroxypropyltimehyl ammonium chloride …

Survivin stands out as one of the most specific cancer targets discovered to date. Although
single inhibition, eg through small interfering RNA (siRNA), has shown modest results in …

Purpose To develop a multifunctional nanoparticle system carrying a combination of pro-
apoptotic drug, NCL-240, TRAIL [tumor necrosis factor-α (TNF-α)-related apoptosis-inducing …

Since clinical application of conventional cancer therapies is usually limited by drug
resistance and toxic side effects, combination of chemotherapeutic agents with gene therapy …