Novel polymeric hybrid nanocarrier for curcumin and survivin shRNA co-delivery augments tumor penetration and promotes synergistic tumor suppression
B Xu, W Zhou, L Cheng, Y Zhou, A Fang, C Jin… - Frontiers in …, 2020 - frontiersin.org
A major barrier for co-delivery of gene medicine with small molecular chemotherapeutic
drugs in solid tumors is the inadequate tumor penetration and transfection. In this study, a …
drugs in solid tumors is the inadequate tumor penetration and transfection. In this study, a …
Targeted nanoparticles harboring jasmine-oil-entrapped paclitaxel for elimination of lung cancer cells
S Engelberg, Y Lin, YG Assaraf, YD Livney - International Journal of …, 2021 - mdpi.com
Selectively targeted drug delivery systems are preferable chemotherapeutic platforms, as
they specifically deliver the drug cargo into tumor cells, while minimizing untoward toxic …
they specifically deliver the drug cargo into tumor cells, while minimizing untoward toxic …
Induction of apoptosis by survivin silencing through siRNA delivery in a human breast cancer cell line
H Montazeri Aliabadi, B Landry… - Molecular …, 2011 - ACS Publications
Post-transcriptional silencing of antiapoptotic genes is a promising strategy for cancer
therapy, but delivering short interfering RNA (siRNA) molecules against such targets is …
therapy, but delivering short interfering RNA (siRNA) molecules against such targets is …
Biodistribution and Pharmacokinetics of Mad2 siRNA-loaded EGFR-Targeted Chitosan Nanoparticles in Cisplatin Sensitive and Resistant Lung Cancer Models
Background: The present study focuses on biodistribution profile and pharmacokinetic
parameters of EGFR-targeted chitosan nanoparticles (TG CS nanoparticles) for …
parameters of EGFR-targeted chitosan nanoparticles (TG CS nanoparticles) for …
5′-triphosphate-siRNA against survivin gene induces interferon production and inhibits proliferation of lung cancer cells in vitro
K Wang, X Chen, F Yan, Y Xing, X Yang… - Journal of …, 2013 - journals.lww.com
Survivin is a new member of the inhibitors of apoptosis family and upregulated in various
human malignancies including human lung cancer. In this study, we proposed a new …
human malignancies including human lung cancer. In this study, we proposed a new …
Evaluation of specific delivery of chimeric phi29 p RNA/siRNA nanoparticles to multiple tumor cells
The pRNA (packaging RNA) of bacteriophage phi29 DNA packaging motor has been
reported to have novel applications in nanotechnology and nanomedicine. The unique …
reported to have novel applications in nanotechnology and nanomedicine. The unique …
Induction of apoptosis and sensitization of head and neck squamous carcinoma cells to cisplatin by targeting survivin gene expression
Z Khan, RP Tiwari, N Khan, G BKS Prasad… - Current gene …, 2012 - ingentaconnect.com
Survivin is known to be highly-expressed in various carcinomas; and is associated with their
biologically aggressive characteristics and drug resistance. We have previously reported …
biologically aggressive characteristics and drug resistance. We have previously reported …
Survivin silencing improved the cytotoxicity of carboplatin and melphalan in Y79 and primary retinoblastoma cells
Survivin stands out as one of the most specific cancer targets discovered to date. Although
single inhibition, eg through small interfering RNA (siRNA), has shown modest results in …
single inhibition, eg through small interfering RNA (siRNA), has shown modest results in …
Simultaneous inhibition of tumor growth and angiogenesis for resistant hepatocellular carcinoma by co-delivery of sorafenib and survivin small hairpin RNA
J Shen, H Sun, Q Meng, Q Yin, Z Zhang… - Molecular …, 2014 - ACS Publications
The development of multidrug resistance (MDR) in human hepatocellular carcinoma (HCC)
is one of the major obstacles for successful chemotherapy of HCC. Co-delivery of sorafenib …
is one of the major obstacles for successful chemotherapy of HCC. Co-delivery of sorafenib …
Nebulized anionic guanidinylated O-carboxymethyl chitosan/N-2-hydroxypropyltimehyl ammonium chloride chitosan nanoparticles for siRNA pulmonary delivery …
S Ni, Y Xie, Y Tang, Y Liu, J Chen… - Journal of Drug Targeting, 2017 - Taylor & Francis
This study developed a pH-sensitive anionic system composed of guanidinylated O-
carboxymethyl chitosan (GOCMCS) and N-2-hydroxypropyltimehyl ammonium chloride …
carboxymethyl chitosan (GOCMCS) and N-2-hydroxypropyltimehyl ammonium chloride …