Purpose The aim of present investigation was to effectively deliver ribonucleotide reductase
subunit 1 (RRM1) targeted siRNA and assess chemo-sensitization of lung cancer cells …

Acquired drug resistance in malignant tumors seriously hinders effective chemotherapy
against cancer. The main mechanisms of drug resistance include decreased drug influx …

Survivin is expressed in most cancers but is undetectable in differentiated adult cells, and
plays an important role both in the suppression of apoptosis and mitotic spindle checkpoint; …

Lung cancer is one of the most lethal diseases worldwide, and the survival rate is less than
15% even after the treatment. Unfortunately, chemotherapeutic treatments for lung cancer …

According to global statistics, cancer is the second leading cause of death worldwide.
Because of the heterogeneity of cancer, single‐drug therapy has many limitations due to low …

A pulmonary codelivery system that can simultaneously deliver doxorubicin (DOX) and Bcl2
siRNA to the lungs provides a promising local treatment strategy for lung cancers. In this …

Background/Aim: Efficient delivery of siRNA is critical for its therapeutic applications. This
study was aimed at the design, synthesis and evaluation of a novel delivery system based …

Expression of survivin has been reported to be correlated with shorter survival in patients
with non-small cell lung cancer (NSCLC), and overexpression of survivin may lead to …

Survivin has been overexpressed in numerous types of cancer and is associated with a poor
clinical outcome. A number of various approaches have been used to counteract survivin in …

Hypoxia inducible factor-1α (HIF-1α) related signaling pathways mediating chemoresistance
has been found in various kinds of cancer, including nasopharyngeal carcinoma (NPC). In …