The neurokinins are a class of peptide signaling molecules that mediate a range of central
and peripheral functions including pain processing, gastrointestinal function, stress …

Stress can trigger drug-seeking behavior, increase self-administration rates, and enhance
drug reward. A number of stress-related neuropeptides have been shown to mediate these …

Rationale Reduced voluntary alcohol consumption was recently found in neurokinin-1
receptor (NK1R)-deficient (KO) mice. It remains unknown whether this reflects …

Addiction is a chronic disorder in which consumption of a substance or a habitual behavior
becomes compulsive and often recurrent, despite adverse consequences. Substance p (SP) …

Abuse of and addiction to psychostimulants such as cocaine or amphetamines remain a
significant societal burden, and attempts at successfully developing effective treatments for …

Substance P (SP) is an 11-amino acid neuropeptide of the tachykinin family that
preferentially activates the neurokinin-1 receptor (NK1R). First isolated 85 years ago and …

Rationale Genetic inactivation or pharmacological antagonism of neurokinin 1 (NK1)
receptors blocks morphine and alcohol reward in rodents, while NK1 antagonism decreases …

SYNOPSIS Neurokinin}(NK3) receptors and their endogenous ligands (eg the neuropeptide
substance Ρ and its C-terminal fragment) have been implicated in psychomotor activity and …

Accumulating evidence suggests that the neuropeptide substance P (SP) and its principal
receptor neurokinin 1 (NK1) play a specific role in the behavioral response to opioids and …

Abstract Neurokinin-1 receptors (NK1Rs) have been shown to mediate alcohol and opiate,
but not cocaine reward in rodents. We recently reported that NK1R antagonism also blocks …