Objectives Neurochemical markers of amyotrophic lateral sclerosis (ALS) that reflect
underlying disease mechanisms might help in diagnosis, staging and prediction of outcome …

Objective Amyotrophic lateral sclerosis (ALS) is a complex disease with numerous
pathological mechanisms resulting in a heterogeneous patient population. Using …

Background Potential biomarkers to aid diagnosis and therapy need to be identified for
Amyotrophic Lateral Sclerosis, a progressive motor neuronal degenerative disorder. The …

The aim of this study was to determine if blood chitotriosidase (Chit) activity and lysosomal
enzyme levels might represent markers of disease activity and progression in amyotrophic …

Objective To evaluate the classifier performance, clinical and biochemical correlations of
cerebrospinal fluid (CSF) levels of the chitinase proteins Chitotriosidase-1 (CHIT1) …

Background Cerebrospinal fluid from amyotrophic lateral sclerosis patients (ALS-CSF)
induces neurodegenerative changes in motor neurons and gliosis in sporadic ALS models …

Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative condition, most widely
characterized by the selective vulnerability of motor neurons and the poor life expectancy of …

Objective To investigate the role of neuroinflammation in asymptomatic and symptomatic
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mutation carriers …

Objective To evaluate the CSF levels of chitinase proteins during the presymptomatic and
early symptomatic phases of amyotrophic lateral sclerosis (ALS). Methods CSF samples …

Objective The neurodegenerative disease, amyotrophic lateral sclerosis (ALS), is a
heterogeneous clinical syndrome involving multiple molecular pathways. The development …