Chronic pain is a major public health issue. Its management mandates a multidisciplinary
clinical assessment. Over the past decades, the individual variation in response to analgesic …

Physicians who treat chronic pain using opioids recognize that patients vary considerably in
their responses to medications and painful stimuli. An increasing body of scientific literature …

The experience of chronic pain is one of the commonest reasons for seeking medical
attention, being a major issue in clinical practice. While pain is a universal experience, only …

Successful pain management requires the delivery of analgesia with minimal risk of adverse
drug reactions. Nonsteroidal anti-inflammatory drugs and opioids remain the mainstay of …

Pain is a common symptom that can be complex to treat. Analgesic medications are the
mainstay treatment, but there is wide interindividual variability in analgesic response and …

This paper reviews the impact of genetic variability of drug metabolizing enzymes,
transporters, receptors, and pathways involved in chronic pain perception on the efficacy …

Purpose This paper summarizes current knowledge of pain-related and analgesic-related
pathways as well as genetic variations involved in pain perception and management …

Pharmacological, surgical, psychological, and alternative medicine approaches for the
treatment of chronic pain, including neuropathic pain, provide only partial relief for most …

Pharmacogenomics is the study of genetic variants that impact drug effects through changes
in a drug's pharmacokinetics and pharmacodynamics. Pharmacogenomics is being …

Genetic research heralds a new therapeutic approach to pain management. Increasing
literature demonstrates individual genetic vulnerabilities to specific pain types and …