PEGylated polypeptide lipid nanocapsules to enhance the anticancer efficacy of erlotinib in non-small cell lung cancer

J Kim, T Ramasamy, JY Choi, ST Kim, YS Youn… - Colloids and Surfaces B …, 2017 - Elsevier
In this study, a core-shell type polypeptide-based lipid nanocapsule was developed to
enhance anticancer efficacy of erlotinib in non-small cell lung cancers. Mean particle size of …

Development and in vitro evaluation of core–shell type lipid–polymer hybrid nanoparticles for the delivery of erlotinib in non-small cell lung cancer

B Mandal, NK Mittal, P Balabathula, LA Thoma… - European journal of …, 2016 - Elsevier
Core–shell type lipid–polymer hybrid nanoparticles (CSLPHNPs) have emerged as a
multifunctional drug delivery platform. The delivery system combines mechanical …

[HTML][HTML] Dual-drug nanosystem: etoposide prodrug and cisplatin coloaded nanostructured lipid carriers for lung cancer therapy

M Du, J Yin - Drug Design, Development and Therapy, 2022 - ncbi.nlm.nih.gov
Purpose Cisplatin (CDDP) and etoposide (Etp) are recommended first-line therapy for lung
cancer. Nanostructured lipid carriers (NLCs) are engineered to deliver drugs for lung cancer …

Paclitaxel and erlotinib-co-loaded solid lipid core nanocapsules: assessment of physicochemical characteristics and cytotoxicity in non-small cell lung cancer

B Gupta, BK Poudel, S Regmi, S Pathak… - Pharmaceutical …, 2018 - Springer
Purpose Lung cancer is the leading cause of cancer-related deaths. The aim of this study
was to design solid lipid core nanocapsules (SLCN) comprising a solid lipid core and a …

[HTML][HTML] Non-small cell lung cancer combination therapy: Hyaluronic acid modified, epidermal growth factor receptor targeted, pH sensitive lipid-polymer hybrid …

J Pang, H Xing, Y Sun, S Feng, S Wang - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality in
China. This study aimed to develop a hyaluronic acid (HA) decorated, pH sensitive lipid …

Co-Delivery of erlotinib and resveratrol via nanostructured lipid Carriers: a synergistically promising approach for cell proliferation prevention and ROS-Mediated …

L Asadollahi, A Mahoutforoush, SS Dorreyatim… - International journal of …, 2022 - Elsevier
Cancer treatments are always associated with various challenges, and scientists are
constantly trying to find new therapies and methods. Erlotinib (ELT) is a well-known …

Enhanced Codelivery of Gefitinib and Azacitidine for Treatment of Metastatic-Resistant Lung Cancer Using Biodegradable Lipid Nanoparticles

EM Elzayat, AY Sherif, FA Nasr, MW Attwa, DH Alshora… - Materials, 2023 - mdpi.com
Lung cancer is a formidable challenge in clinical practice owing to its metastatic nature and
resistance to conventional treatments. The codelivery of anticancer agents offers a potential …

Novel therapeutic modalities and drug delivery – erlotinib liposomes modified with galactosylated lipid: in vitro and in vivo investigations

H Xu, C He, Y Liu, J Jiang, T Ma - Artificial cells, nanomedicine …, 2018 - Taylor & Francis
The aim of this study to develop galactosylated erlotinib liposomes for treatment of lung
cancer. The liposomes were prepared by using solvent evaporation method. Various …

Gefitinib encapsulation based on nano-liposomes for enhancing the curative effect of lung cancer

Y Hu, J Zhang, H Hu, S Xu, L Xu, E Chen - Cell Cycle, 2020 - Taylor & Francis
Gefitinib (GEB) is one of the drugs used for patients with epidermal growth factor receptor
(EGFR)-positive mutations in non-small cell lung cancer (NSCLC). However, application of …

Optimization of gefitinib-loaded nanostructured lipid carrier as a biomedical tool in the treatment of metastatic lung cancer

AY Sherif, GI Harisa, AA Shahba, FK Alanazi, W Qamar - Molecules, 2023 - mdpi.com
Gefitinib (GEF) is utilized in clinical settings for the treatment of metastatic lung cancer.
However, premature drug release from nanoparticles in vivo increases the exposure of …