Insulin resistance and a progressive decline in functional β‐cell mass are hallmarks of
developing type 2 diabetes (T2D). Thus, searching for natural, low‐cost compounds to target …

Considerable evidence shows that chronic hyperglycemia can cause pancreatic beta-cell
dysfunction, which contributes to progressive deterioration of glucose homeostasis and overt …

In diabetes mellitus, the excessive rate of glucose production from the liver is considered a
primary contributor for the development of hyperglycemia, in particular, fasting …

Obesity-associated insulin resistance (IR) is a major risk factor for developing type 2
diabetes and an array of other metabolic disorders. In particular, hepatic IR contributes to the …

While peripheral insulin resistance is common during obesity and aging in mice and people,
the progression to type 2 diabetes (T2D) is largely due to loss of β-cell mass and function …

Kaempferol is a dietary flavanol that regulates cellular lipid and glucose metabolism. Its
mechanism of action in preventing hepatic steatosis and obesity‐related disorders has yet to …

Recent studies show that inflammation underlies the metabolic disorders of insulin
resistance and type 2 diabetes mellitus. Since kaempferol, a naturally occurring flavonoid …

Kaempferol, a natural flavonoid, has the beneficial effects of preserving pancreatic β-cell
mass and function, but its action on β-cell lipid metabolism still remains elusive. Recently …

Obesity–insulin resistance–β-cells apoptosis” is an important trilogy of the pathogenesis of
type 2 diabetes. With the global pandemic of obesity and diabetes, continuous research and …

Chronic hyperlipidemia causes β-cell apoptosis and dysfunction, thereby contributing to the
pathogenesis of type 2 diabetes (T2D). Thus, searching for agents to promote pancreatic β …