[Retracted] Small Molecule Kaempferol Promotes Insulin Sensitivity and Preserved Pancreatic β‐Cell Mass in Middle‐Aged Obese Diabetic Mice
H Alkhalidy, W Moore, Y Zhang… - Journal of diabetes …, 2015 - Wiley Online Library
Insulin resistance and a progressive decline in functional β‐cell mass are hallmarks of
developing type 2 diabetes (T2D). Thus, searching for natural, low‐cost compounds to target …
developing type 2 diabetes (T2D). Thus, searching for natural, low‐cost compounds to target …
Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function
Y Zhang, D Liu - European journal of pharmacology, 2011 - Elsevier
Considerable evidence shows that chronic hyperglycemia can cause pancreatic beta-cell
dysfunction, which contributes to progressive deterioration of glucose homeostasis and overt …
dysfunction, which contributes to progressive deterioration of glucose homeostasis and overt …
[HTML][HTML] The flavonoid kaempferol ameliorates streptozotocin-induced diabetes by suppressing hepatic glucose production
In diabetes mellitus, the excessive rate of glucose production from the liver is considered a
primary contributor for the development of hyperglycemia, in particular, fasting …
primary contributor for the development of hyperglycemia, in particular, fasting …
Kaempferol ameliorates hyperglycemia through suppressing hepatic gluconeogenesis and enhancing hepatic insulin sensitivity in diet-induced obese mice
H Alkhalidy, W Moore, A Wang, J Luo… - The Journal of nutritional …, 2018 - Elsevier
Obesity-associated insulin resistance (IR) is a major risk factor for developing type 2
diabetes and an array of other metabolic disorders. In particular, hepatic IR contributes to the …
diabetes and an array of other metabolic disorders. In particular, hepatic IR contributes to the …
Genistein ameliorates hyperglycemia in a mouse model of nongenetic type 2 diabetes
Z Fu, ER Gilbert, L Pfeiffer, Y Zhang… - Applied Physiology …, 2012 - cdnsciencepub.com
While peripheral insulin resistance is common during obesity and aging in mice and people,
the progression to type 2 diabetes (T2D) is largely due to loss of β-cell mass and function …
the progression to type 2 diabetes (T2D) is largely due to loss of β-cell mass and function …
Preventive effects of kaempferol on high‐fat diet‐induced obesity complications in C57BL/6 mice
T Wang, Q Wu, T Zhao - BioMed research international, 2020 - Wiley Online Library
Kaempferol is a dietary flavanol that regulates cellular lipid and glucose metabolism. Its
mechanism of action in preventing hepatic steatosis and obesity‐related disorders has yet to …
mechanism of action in preventing hepatic steatosis and obesity‐related disorders has yet to …
Kaempferol alleviates insulin resistance via hepatic IKK/NF-κB signal in type 2 diabetic rats
C Luo, H Yang, C Tang, G Yao, L Kong, H He… - International …, 2015 - Elsevier
Recent studies show that inflammation underlies the metabolic disorders of insulin
resistance and type 2 diabetes mellitus. Since kaempferol, a naturally occurring flavonoid …
resistance and type 2 diabetes mellitus. Since kaempferol, a naturally occurring flavonoid …
Kaempferol alleviates palmitic acid-induced lipid stores, endoplasmic reticulum stress and pancreatic β-cell dysfunction through AMPK/mTOR-mediated lipophagy
Kaempferol, a natural flavonoid, has the beneficial effects of preserving pancreatic β-cell
mass and function, but its action on β-cell lipid metabolism still remains elusive. Recently …
mass and function, but its action on β-cell lipid metabolism still remains elusive. Recently …
[HTML][HTML] Mechanisms of Kaempferol in the treatment of diabetes: A comprehensive and latest review
Y Yang, Z Chen, X Zhao, H Xie, L Du, H Gao… - Frontiers in …, 2022 - frontiersin.org
Obesity–insulin resistance–β-cells apoptosis” is an important trilogy of the pathogenesis of
type 2 diabetes. With the global pandemic of obesity and diabetes, continuous research and …
type 2 diabetes. With the global pandemic of obesity and diabetes, continuous research and …
Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB
Y Zhang, W Zhen, P Maechler, D Liu - The Journal of Nutritional …, 2013 - Elsevier
Chronic hyperlipidemia causes β-cell apoptosis and dysfunction, thereby contributing to the
pathogenesis of type 2 diabetes (T2D). Thus, searching for agents to promote pancreatic β …
pathogenesis of type 2 diabetes (T2D). Thus, searching for agents to promote pancreatic β …