Background Nuclear factor erythroid-2-related factor-2 (Nrf2) is known to protect against
tissue injury by orchestrating antioxidant and detoxification responses to oxidative stress …

Background Renal interstitial fibrosis is a common final pathological process in the
progression of kidney disease. This is primarily due to oxidative stress, which contributes to …

Abstract Background Cyclosporine-A (CsA) is an immunosuppressant indicated for various
immunological diseases; however, it can induce chronic kidney injury. Oxidative stress and …

Fluorofenidone (AKF-PD) is a novel pyridone agent that reduces the deposition of
extracellular matrix (ECM) in various models of renal fibrosis. However, there are no reports …

Calcineurin inhibitors, such as Cyclosporin (CsA), are the mainstay of anti-rejection therapy
in solid organ transplants but can paradoxically induce progressive nephropathy …

Cyclosporine is one of the main immunosuppressive agents used in the treatment of
autoimmune diseases or transplantation. Despite the favorable effects, cyclosporine …

This study evaluated effect of oxalate on epithelial mesenchymal transition (EMT) and
potential anti-fibrotic property of epigallocatechin-3-gallate (EGCG). MDCK renal tubular …

Aims Cyclophosphamide is an alkylating agent with vast arrays of therapeutic activity.
Currently, its medical use is limited due to its numerous adverse events, including …

Hyperoxaluria induces oxidative stress, and inflammation causes renal epithelial cell injury
in nephrolithiasis, suggesting that reduced oxalate toxicity may be beneficial. This study …

Besides its effect on high blood pressure, T-type calcium channel blocker is renoprotective
in experimental models of renal fibrosis. However, the exact mechanism of T-type calcium …