Chronic fragmentation of the daily sleep-wake rhythm increases amyloid-beta levels and neuroinflammation in the 3xTg-AD mouse model of Alzheimer's disease

MJ Duncan, LE Guerriero, K Kohler, LE Beechem… - Neuroscience, 2022 - Elsevier
Fragmentation of the daily sleep-wake rhythm with increased nighttime awakenings and
more daytime naps is correlated with the risk of development of Alzheimer's disease (AD) …

Alzheimer's disease and sleep–wake disturbances: Amyloid, astrocytes, and animal models

WM Vanderheyden, MM Lim, ES Musiek… - Journal of …, 2018 - Soc Neuroscience
Sleep–wake abnormalities are common in patients with Alzheimer's disease, and can be a
major reason for institutionalization. However, an emerging concept is that these sleep …

[HTML][HTML] Amyloid-β diurnal pattern: possible role of sleep in Alzheimer's disease pathogenesis

BP Lucey, RJ Bateman - Neurobiology of aging, 2014 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
cognitive decline that is a growing public health crisis with a prevalence projected to more …

Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors

C Wang, DM Holtzman - Neuropsychopharmacology, 2020 - nature.com
As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

Chronic sleep fragmentation exacerbates amyloid β deposition in Alzheimer's disease model mice

EN Minakawa, K Miyazaki, K Maruo, H Yagihara… - Neuroscience …, 2017 - Elsevier
Sleep fragmentation due to intermittent nocturnal arousal resulting in a reduction of total
sleep time and sleep efficiency is a common symptom among people with Alzheimer's …

Chronic sleep restriction increases soluble hippocampal Aβ-42 and impairs cognitive performance

KN Brice, CW Hagen, JL Peterman, JW Figg… - Physiology & …, 2020 - Elsevier
Currently, over 44 million people worldwide suffer from Alzheimer's disease (AD). A common
feature of AD is disrupted sleep. Sleep is essential for many psychological and physiological …

The sleep–wake cycle and Alzheimer's disease: what do we know?

MM Lim, JR Gerstner, DM Holtzman - Neurodegenerative disease …, 2014 - Future Medicine
Sleep–wake disturbances are a highly prevalent and often disabling feature of Alzheimer's
disease (AD). A cardinal feature of AD includes the formation of amyloid plaques, associated …

Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice

GC Kincheski, IS Valentim, JR Clarke… - Brain, behavior, and …, 2017 - Elsevier
It is increasingly recognized that sleep disturbances and Alzheimer's disease (AD) share a
bidirectional relationship. AD patients exhibit sleep problems and alterations in the …

[HTML][HTML] Sleep alleviates AD-related neuropathological processes

H Malkki - Nature reviews Neurology, 2013 - nature.com
Sleep disturbances have previously been associated with Alzheimer disease (AD) and age-
related cognitive decline. Now, three studies have addressed the link between sleep and …

Thermoneutral temperature exposure enhances slow-wave sleep with a correlated improvement in amyloid pathology in a triple-transgenic mouse model of …

J Wang, D Huffman, A Ajwad, CJ McLouth… - Sleep, 2024 - academic.oup.com
Accumulation of amyloid‐β (Aβ) plays an important role in Alzheimer's disease (AD)
pathology. There is growing evidence that disordered sleep may accelerate AD pathology …