Aggregation of amyloid-β (Aβ) in the brain begins to occur years prior to the clinical onset of
Alzheimer's disease (AD). Prior to Aβ aggregation, levels of extracellular, soluble interstitial …

Abstract Study Objectives Accumulating evidence suggests a strong association between
sleep, amyloid-beta (Aβ) deposition, and Alzheimer's disease (AD). We sought to determine …

While efficient treatments for Alzheimer's disease (AD) remain elusive, a growing body of
research has highlighted sleep–wake regulation as a potential modifiable factor to delay …

Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterized by
progressive hippocampal-dependent explicit memory deficits that begin at the onset of the …

The Tg2576 mouse model of Alzheimer's disease (AD) exhibits age-dependent amyloid β
(Aβ) deposition in the brain. We studied electroencephalographically defined sleep and the …

Sleep disturbances are associated with future risk of Alzheimer disease. Disrupted sleep
increases soluble amyloid β, suggesting a mechanism for sleep disturbances to increase …

Circadian disturbances, including a fragmented sleep–wake pattern and sundowning, are
commonly reported early in the progression of Alzheimer's disease (AD). These changes are …

Disturbances in the sleep–wake cycle and circadian rhythms are common symptoms of
Alzheimer Disease (AD), and they have generally been considered as late consequences of …

This study aimed to identify differences between physiological age-related and Alzheimer's
disease (AD)-related alterations in sleep and rest-activity rhythm. All participants (n= 280; 20 …

Sleep abnormalities are widely reported in patients with Alzheimer's disease (AD) and are
linked to cognitive impairments. Sleep abnormalities could be potential biomarkers to detect …