Alterations of sleep oscillations in Alzheimer's disease: a potential role for GABAergic neurons in the cortex, hippocampus, and thalamus
Sleep abnormalities are widely reported in patients with Alzheimer's disease (AD) and are
linked to cognitive impairments. Sleep abnormalities could be potential biomarkers to detect …
linked to cognitive impairments. Sleep abnormalities could be potential biomarkers to detect …
Neuroinflammation and tau interact with amyloid in predicting sleep problems in aging independently of atrophy
Sleep problems relate to brain changes in aging and disease, but the mechanisms are
unknown. Studies suggest a relationship between β-amyloid (Aβ) accumulation and sleep …
unknown. Studies suggest a relationship between β-amyloid (Aβ) accumulation and sleep …
Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels
YES Ju, SJ Ooms, C Sutphen, SL Macauley… - Brain, 2017 - academic.oup.com
See Mander et al.(doi: 10.1093/awx174) for a scientific commentary on this article. Sleep
deprivation increases amyloid-β, suggesting that chronically disrupted sleep may promote …
deprivation increases amyloid-β, suggesting that chronically disrupted sleep may promote …
Sleep disturbance: an early sign of Alzheimer's disease
C He, Z Hu, C Jiang - Neuroscience Bulletin, 2020 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
cognitive impairment in older adults. The accumulation of insoluble forms of amyloid-b (Ab) …
cognitive impairment in older adults. The accumulation of insoluble forms of amyloid-b (Ab) …
[HTML][HTML] Sleep in Alzheimer's disease–beyond amyloid
JK Holth, TK Patel, DM Holtzman - Neurobiology of sleep and circadian …, 2017 - Elsevier
Sleep disorders are prevalent in Alzheimer's disease (AD) and a major cause of
institutionalization. Like AD pathology, sleep abnormalities can appear years before …
institutionalization. Like AD pathology, sleep abnormalities can appear years before …
Late-in-life neurodegeneration after chronic sleep loss in young adult mice
JE Owen, Y Zhu, P Fenik, G Zhan, P Bell, C Liu… - Sleep, 2021 - academic.oup.com
Chronic short sleep (CSS) is prevalent in modern societies and has been proposed as a risk
factor for Alzheimer's disease (AD). In support, short-term sleep loss acutely increases levels …
factor for Alzheimer's disease (AD). In support, short-term sleep loss acutely increases levels …
Sleep moderates the relationship between amyloid beta and memory recall
Amyloid-β (Aβ) accumulation is a hallmark of Alzheimer's disease, although Aβ alone may
be insufficient to cause impairments. Modifiable health factors, including sleep, may mitigate …
be insufficient to cause impairments. Modifiable health factors, including sleep, may mitigate …
[HTML][HTML] Does chronic sleep fragmentation lead to Alzheimer's disease in young wild-type mice?
L Ba, L Huang, Z He, S Deng, Y Xie… - Frontiers in Aging …, 2021 - frontiersin.org
Chronic sleep insufficiency is becoming a common issue in the young population nowadays,
mostly due to life habits and work stress. Studies in animal models of neurological diseases …
mostly due to life habits and work stress. Studies in animal models of neurological diseases …
The sleep side of aging and Alzheimer's disease
As we age, sleep patterns undergo significant modifications in micro and macrostructure,
worsening cognition and quality of life. These are associated with remarkable brain …
worsening cognition and quality of life. These are associated with remarkable brain …
Sleep: a novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer's disease?
Sleep disruption appears to be a core component of Alzheimer's disease (AD) and its
pathophysiology. Signature abnormalities of sleep emerge before clinical onset of AD …
pathophysiology. Signature abnormalities of sleep emerge before clinical onset of AD …