Alterations of sleep oscillations in Alzheimer's disease: a potential role for GABAergic neurons in the cortex, hippocampus, and thalamus

F Katsuki, D Gerashchenko, RE Brown - Brain research bulletin, 2022 - Elsevier
Sleep abnormalities are widely reported in patients with Alzheimer's disease (AD) and are
linked to cognitive impairments. Sleep abnormalities could be potential biomarkers to detect …

Neuroinflammation and tau interact with amyloid in predicting sleep problems in aging independently of atrophy

AM Fjell, AV Idland, R Sala-Llonch, LO Watne… - Cerebral …, 2018 - academic.oup.com
Sleep problems relate to brain changes in aging and disease, but the mechanisms are
unknown. Studies suggest a relationship between β-amyloid (Aβ) accumulation and sleep …

Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels

YES Ju, SJ Ooms, C Sutphen, SL Macauley… - Brain, 2017 - academic.oup.com
See Mander et al.(doi: 10.1093/awx174) for a scientific commentary on this article. Sleep
deprivation increases amyloid-β, suggesting that chronically disrupted sleep may promote …

Sleep disturbance: an early sign of Alzheimer's disease

C He, Z Hu, C Jiang - Neuroscience Bulletin, 2020 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
cognitive impairment in older adults. The accumulation of insoluble forms of amyloid-b (Ab) …

[HTML][HTML] Sleep in Alzheimer's disease–beyond amyloid

JK Holth, TK Patel, DM Holtzman - Neurobiology of sleep and circadian …, 2017 - Elsevier
Sleep disorders are prevalent in Alzheimer's disease (AD) and a major cause of
institutionalization. Like AD pathology, sleep abnormalities can appear years before …

Late-in-life neurodegeneration after chronic sleep loss in young adult mice

JE Owen, Y Zhu, P Fenik, G Zhan, P Bell, C Liu… - Sleep, 2021 - academic.oup.com
Chronic short sleep (CSS) is prevalent in modern societies and has been proposed as a risk
factor for Alzheimer's disease (AD). In support, short-term sleep loss acutely increases levels …

Sleep moderates the relationship between amyloid beta and memory recall

KA Wilckens, DL Tudorascu, BE Snitz, JC Price… - Neurobiology of …, 2018 - Elsevier
Amyloid-β (Aβ) accumulation is a hallmark of Alzheimer's disease, although Aβ alone may
be insufficient to cause impairments. Modifiable health factors, including sleep, may mitigate …

[HTML][HTML] Does chronic sleep fragmentation lead to Alzheimer's disease in young wild-type mice?

L Ba, L Huang, Z He, S Deng, Y Xie… - Frontiers in Aging …, 2021 - frontiersin.org
Chronic sleep insufficiency is becoming a common issue in the young population nowadays,
mostly due to life habits and work stress. Studies in animal models of neurological diseases …

The sleep side of aging and Alzheimer's disease

SM Romanella, D Roe, E Tatti, D Cappon, R Paciorek… - Sleep medicine, 2021 - Elsevier
As we age, sleep patterns undergo significant modifications in micro and macrostructure,
worsening cognition and quality of life. These are associated with remarkable brain …

Sleep: a novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer's disease?

BA Mander, JR Winer, WJ Jagust, MP Walker - Trends in neurosciences, 2016 - cell.com
Sleep disruption appears to be a core component of Alzheimer's disease (AD) and its
pathophysiology. Signature abnormalities of sleep emerge before clinical onset of AD …