Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective

S Nattel, J Heijman, L Zhou, D Dobrev - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

[HTML][HTML] Recent advances in the molecular pathophysiology of atrial fibrillation

R Wakili, N Voigt, S Kääb, D Dobrev… - The Journal of clinical …, 2011 - Am Soc Clin Investig
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …

Atrial fibrillation

BJJM Brundel, X Ai, MT Hills… - Nature reviews …, 2022 - ohiostate.elsevierpure.com
Atrial fibrillation (AF) is the most common cardiac arrhythmia despite substantial efforts to
understand the pathophysiology of the condition and develop improved treatments …

Mechanisms of atrial fibrillation

RS Wijesurendra, B Casadei - Heart, 2019 - heart.bmj.com
Atrial fibrillation (AF) is the most common sustained arrhythmia, currently affecting over 33
million individuals worldwide, and its prevalence is expected to more than double over the …

Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

J Heijman, N Voigt, S Nattel, D Dobrev - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Therapeutic implications of atrial fibrillation mechanisms: can mechanistic insights be used to improve AF management?

S Nattel - Cardiovascular research, 2002 - academic.oup.com
Atrial fibrillation (AF) is a very common clinical problem, and presently available treatment
options are suboptimal. A tremendous amount has been learned over the past 10 years …

Mechanisms and drug development in atrial fibrillation

D Calvo, D Filgueiras-Rama, J Jalife - Pharmacological Reviews, 2018 - ASPET
Atrial fibrillation is a highly prevalent cardiac arrhythmia and the most important cause of
embolic stroke. Although genetic studies have identified an increasing assembly of AF …

Advances in basic and translational research in atrial fibrillation

D Hu, H Barajas-Martinez… - … of the Royal …, 2023 - royalsocietypublishing.org
Atrial fibrillation (AF) is a very common cardiac arrhythmia with an estimated prevalence of
33.5 million patients globally. It is associated with an increased risk of death, stroke and …

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis

J Heijman, V Algalarrondo, N Voigt… - Cardiovascular …, 2016 - academic.oup.com
Atrial fibrillation (AF) is an extremely common clinical problem associated with increased
morbidity and mortality. Current antiarrhythmic options include pharmacological, ablation …

Electrical remodeling in atrial fibrillation

D Dobrev - Herz, 2006 - search.proquest.com
Electrical remodeling refers to any change in electrical function that promotes atrial
fibrillation (AF). A key advance in understanding the mechanisms of AF has been the …