In-vitro oral bioaccessibility tests do remain alluring as viable tools for fast assessment of
potential human exposure to environmental contaminants to comply with the ethical …

Transporter proteins are known to play a critical role in affecting the overall absorption,
distribution, metabolism, and excretion characteristics of drug candidates. In addition to …

The purpose of the present study was to evaluate and compare the absolute protein
expression levels of 28 drug-related transporters in Caco-2 cell monolayers cultured for 2, 3 …

This paper describes the applicability of in vitro digestion models as a tool for consumer
products in (ad hoc) risk assessment. In current risk assessment, oral bioavailability from a …

Previous in vitro and clinical research have indicated that a wide variety of drug transporters
as well as metabolic enzymes dominate the pharmacokinetics of drugs and that some drugs …

Robust, predictive ex vivo/in vitro models to study intestinal drug absorption by passive and
active transport mechanisms are scarce. Membrane transporters can significantly impact …

Prediction of intestinal availability (FG), in conjunction with hepatic metabolism, is of
considerable importance in drug disposition to assess oral clearance and liability to drug …

Environmental risk assessment requires models for estimating the bioaccumulation of
untested compounds. So far, bioaccumulation models have focused on lipophilic …

Drug transporters are now universally acknowledged as important determinants of the
absorption, distribution, metabolism and excretion of both endogenous and exogenous …

Biliary excretion (BE) is a major elimination pathway, and its prediction is particularly
important for optimization of systemic and/or target-site exposure of new molecular entities …