Tissue drug concentrations determine the efficacy and toxicity of drugs. When a drug is the
substrate of transporters that are present at the blood: tissue barrier, the steady‐state …

Human bioaccumulative potential is an important element in the risk assessment of
chemicals. Due to the high number of synthetic chemicals, there exists the need to develop …

Purpose Membrane transporters mediate many biological effects of chemicals and play a
major role in pharmacokinetics and drug resistance. The selection of viable drug candidates …

The aim of precision medicine is to improve health care by tailoring drug treatment to
patientsL individual characteristics through the integration of knowledge explaining …

For in vitro to in vivo extrapolation (IVIVE) of brain distribution of drugs that are transported at
the human blood–brain barrier (BBB), it is important to quantify the interindividual and …

During development, the maturation of liver transporters is essential for chemical elimination
in newborns and children. One cannot compare the real abundance of transcripts by …

Xenobiotics from anthropogenic and natural origin enter animal feed and human food as
regulated compounds, environmental contaminants or as part of components of the diet …

Humans respond to chemical exposures differently due to many factors, such as previous
and concurrent stressors, age, sex, and genetic background. The vast majority of laboratory …

Membrane transporters play a pivotal role in many organs to maintain their normal
physiological functions and contribute significantly to drug absorption, distribution, and …

Prediction of human pharmacokinetic profiles of drug candidates is an essential step toward
first-in-human studies. However, it remains difficult to quantitatively predict hepatic …