Guidelines for in vivo mouse models of myocardial infarction

ML Lindsey, KR Brunt, JA Kirk… - American Journal …, 2021 - journals.physiology.org
Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

Guidelines for experimental models of myocardial ischemia and infarction

ML Lindsey, R Bolli, JM Canty Jr… - American Journal …, 2018 - journals.physiology.org
Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

Preclinical models of myocardial infarction: from mechanism to translation

TP Martin, EA MacDonald… - British Journal of …, 2022 - Wiley Online Library
Approximately 7 million people are affected by acute myocardial infarction (MI) each year,
and despite significant therapeutic and diagnostic advancements, MI remains a leading …

Animal models of myocardial infarction: Mainstay in clinical translation

M Kumar, ER Kasala, LN Bodduluru, V Dahiya… - Regulatory Toxicology …, 2016 - Elsevier
Preclinical models with high prognostic power are a prerequisite for translational research.
The closer the similarity of a model to myocardial infarction (MI), the higher is the prognostic …

Rat models of myocardial infarction

R Bhindi, PK Witting, AC McMahon… - Thrombosis and …, 2006 - thieme-connect.com
Animal models of cardiovascular pathology contribute towards understanding and treatment
of a broad range of conditions. Specifically in the context of acute myocardial infarction …

Acute myocardial infarction in rats

Y Wu, X Yin, C Wijaya, MH Huang… - JoVE (Journal of …, 2011 - jove.com
With heart failure leading the cause of death in the USA (Hunt), biomedical research is
fundamental to advance medical treatments for cardiovascular diseases. Animal models that …

Myocardial infarction and intramyocardial injection models in swine

FC McCall, KS Telukuntla, V Karantalis, VY Suncion… - Nature protocols, 2012 - nature.com
Sustainable and reproducible large animal models that closely replicate the clinical
sequelae of myocardial infarction (MI) are important for the translation of basic science …

Reperfused vs. nonreperfused myocardial infarction: when to use which model

ML Lindsey, LE de Castro Brás… - American Journal …, 2021 - journals.physiology.org
There is a lack of understanding in the cardiac remodeling field regarding the use of
nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This …

Mouse models of myocardial infarction: comparing permanent ligation and ischaemia-reperfusion

C De Villiers, PR Riley - Disease Models & Mechanisms, 2020 - journals.biologists.com
Myocardial infarction (MI) is a disease of major consequence in the modern world, causing
permanent, irreversible damage to the heart. Survivors are at risk for developing further …

Human tissue-engineered model of myocardial ischemia–reperfusion injury

T Chen, G Vunjak-Novakovic - Tissue Engineering Part A, 2019 - liebertpub.com
Ischemia–reperfusion injury (IRI) is a major, but potentially preventable contributor to the
final tissue damage after an acute myocardial infarction. Many therapies have demonstrated …