Minocycline relieves depressive-like behaviors in rats with bone cancer pain by inhibiting microglia activation in hippocampus
J Dai, Z Ding, J Zhang, W Xu, Q Guo, W Zou… - Anesthesia & …, 2019 - journals.lww.com
BACKGROUND: Pain and depression are highly prevalent symptoms in cancer patients.
They tend to occur simultaneously and affect each other and share biological pathways and …
They tend to occur simultaneously and affect each other and share biological pathways and …
[HTML][HTML] Minocycline attenuates bone cancer pain in rats by inhibiting NF-κB in spinal astrocytes
Z Song, B Xiong, X Guan, F Cao, A Manyande… - Acta Pharmacologica …, 2016 - nature.com
Aim: To investigate the mechanisms underlying the anti-nociceptive effect of minocycline on
bone cancer pain (BCP) in rats. Methods: A rat model of BCP was established by inoculating …
bone cancer pain (BCP) in rats. Methods: A rat model of BCP was established by inoculating …
Chronic intrathecal infusion of minocycline prevents the development of spinal-nerve ligation-induced pain in rats
CS Lin, ML Tsaur, CC Chen, TY Wang… - Regional Anesthesia & …, 2007 - rapm.bmj.com
Background and Objectives Minocycline is a second-generation tetracycline with multiple
biological effects, including inhibition of microglial activation. Recently, microglial activation …
biological effects, including inhibition of microglial activation. Recently, microglial activation …
[HTML][HTML] Microglia are involved in pain related behaviors during the acute and chronic phase of arthritis inflammation
Background: Pain is one of the main protests of inflammatory diseases, hence,
understanding the mechanisms which involved in the induction and persistence of pain is …
understanding the mechanisms which involved in the induction and persistence of pain is …
Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression
There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …
association between chronic pain and depression. The current study examined the effect of …
A novel role of minocycline: attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia
Y Cui, XX Liao, W Liu, RX Guo, ZZ Wu, CM Zhao… - Brain, behavior, and …, 2008 - Elsevier
We have previously demonstrated that activation of p38 mitogen-activated protein kinase
(p38 MAPK) in the spinal microglia mediates morphine antinociceptive tolerance …
(p38 MAPK) in the spinal microglia mediates morphine antinociceptive tolerance …
Melatonin attenuates pain hypersensitivity and decreases astrocyte-mediated spinal neuroinflammation in a rat model of oxaliplatin-induced pain
Y Wang, Y Li, W Cui, L Li, Z Zhang, B Tian, G Zhang - Inflammation, 2017 - Springer
Neuroinflammatory response in spinal dorsal horn has been demonstrated to be a critical
factor in oxaliplatin-induced pain. Melatonin has been shown to have anti-inflammatory and …
factor in oxaliplatin-induced pain. Melatonin has been shown to have anti-inflammatory and …
[HTML][HTML] The role of the M1/M2 microglia in the process from cancer pain to morphine tolerance
H Tu, H Chu, S Guan, F Hao, N Xu, Z Zhao, Y Liang - Tissue and Cell, 2021 - Elsevier
Cancer pain, especially bone cancer pain, is a pain state often caused by inflammation or
dysfunctional nerves. Moreover, in the management of cancer pain, opioid especially …
dysfunctional nerves. Moreover, in the management of cancer pain, opioid especially …
Minocycline attenuates post‐operative cognitive impairment in aged mice by inhibiting microglia activation
HL Wang, H Liu, ZG Xue, QW Liao… - Journal of cellular and …, 2016 - Wiley Online Library
Although it is known that isoflurane exposure or surgery leads to post‐operative cognitive
dysfunction in aged rodents, there are few clinical interventions and treatments available to …
dysfunction in aged rodents, there are few clinical interventions and treatments available to …
Minocycline and fluorocitrate suppress spinal nociceptive signaling in intrathecal IL‐1β–induced thermal hyperalgesic rats
We previously demonstrated that intrathecal IL‐1β caused thermal hyperalgesia in rats. This
study was conducted to examine the effects and cellular mechanisms of glial inhibitors on IL …
study was conducted to examine the effects and cellular mechanisms of glial inhibitors on IL …